SF3B1 and MELK

Number of citations of the paper that reports this interaction (PMID 16216881)
21

Data Source:
HPRD (in vitro)

		SF3B1	MELK
Gene Name		splicing factor 3b, subunit 1, 155kDa	maternal embryonic leucine zipper kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nuclear Speck Catalytic Step 2 Spliceosome	Plasma Membrane Cell Cortex Membrane
	Molecular Function	Chromatin Binding Protein Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Anterior/posterior Pattern Specification Gene Expression	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: APBB1 C11orf58 CALM1 CSNK2A1 DYRK1A ERG IL7R MELK MYC NUDT21 PLRG1 PPP1R8 PRPF40A RBM17 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 TCERG1 TOP1 UBC WBP4	9 interactors: CDC25B CDC5L EIF2S1 HIST1H1B LMNB1 MBP PPP1R8 SF3B1 ZNF622
Entrez ID		23451	9833
HPRD ID		09281	06119
Ensembl ID		ENSG00000115524	ENSG00000165304
Uniprot IDs		A0JLT9 O75533 Q7Z497	B7Z1G6 Q14680
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV	4BKY 4BKZ 4BL1 4IXP
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transforming Growth Factor Beta Receptor Signaling Pathway Phosphorylation Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription, DNA-templated Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development RNA Biosynthetic Process Osteoblast Fate Commitment Mullerian Duct Regression Regulation Of Nitrogen Compound Metabolic Process Kidney Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Cycle Phosphate-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Macromolecule Biosynthetic Process Midbrain Development Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Division Anatomical Structure Regression Signal Transduction By Phosphorylation Transcription From RNA Polymerase II Promoter Cellular Response To BMP Stimulus Enzyme Linked Receptor Protein Signaling Pathway Protein Phosphorylation Kidney Development Rhythmic Process	RNA Splicing MRNA Processing Positive Regulation Of Kinase Activity MRNA Metabolic Process Positive Regulation Of Transferase Activity RNA Processing Defense Response To Nematode
Tagcloud ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately stratification tp53 un	axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Difference) ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately stratification tp53 un	axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Intersection) ?