SF3B1 and DYRK1A

Number of citations of the paper that reports this interaction (PMID 16512921)
14

Data Source:
HPRD (in vivo, in vitro)

		SF3B1	DYRK1A
Gene Name		splicing factor 3b, subunit 1, 155kDa	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Protein Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Anterior/posterior Pattern Specification Gene Expression	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Positive Regulation Of Protein Deacetylation
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway	G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		24 interactors: APBB1 C11orf58 CALM1 CSNK2A1 DYRK1A ERG IL7R MELK MYC NUDT21 PLRG1 PPP1R8 PRPF40A RBM17 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 TCERG1 TOP1 UBC WBP4	26 interactors: AMPH APP CCNL2 CLASRP CREB1 FOXO1 GLI1 HIST1H2BB HIST1H3A HIST1H4A LATS2 LIN52 LZTS2 PHYHIP PRD RB1 RBL1 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG
Entrez ID		23451	1859
HPRD ID		09281	09018
Ensembl ID		ENSG00000115524	ENSG00000157540
Uniprot IDs		A0JLT9 O75533 Q7Z497	F8WAP0 Q13627
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV	2VX3 2WO6 3ANQ 3ANR 4AZE
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transforming Growth Factor Beta Receptor Signaling Pathway Phosphorylation Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription, DNA-templated Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development RNA Biosynthetic Process Osteoblast Fate Commitment Mullerian Duct Regression Regulation Of Nitrogen Compound Metabolic Process Kidney Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Cycle Phosphate-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Macromolecule Biosynthetic Process Midbrain Development Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Division Anatomical Structure Regression Signal Transduction By Phosphorylation Transcription From RNA Polymerase II Promoter Cellular Response To BMP Stimulus Enzyme Linked Receptor Protein Signaling Pathway Protein Phosphorylation Kidney Development Rhythmic Process	Gene Expression Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA 3'-end Processing Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process MRNA Processing Negative Regulation Of Gene Expression RNA 3'-end Processing RNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear Export Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation MRNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process RNA Splicing Response To Growth Factor Positive Regulation Of Mitochondrion Organization Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Apoptotic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway
Tagcloud ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately stratification tp53 un	abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Difference) ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately stratification tp53 un	abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Intersection) ?