TARDBP and EXOSC10

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TARDBP	EXOSC10
Gene Name		TAR DNA binding protein	exosome component 10
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Nuclear Speck Interchromatin Granule	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Transcriptionally Active Chromatin
	Molecular Function	Nucleotide Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Nucleotide Binding Exoribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Stabilization	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		16 interactors: APP EXOSC10 FUS GNB2L1 IRAK2 LSM6 MED6 NACC1 NSFL1C RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	35 interactors: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 MPP6 NOMO1 NOMO2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 TARDBP TOX4 UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		23435	5394
HPRD ID		05466	16180
Ensembl ID			ENSG00000171824
Uniprot IDs		B1AKP7 B4DJ45 Q13148 Q9H256	Q01780 Q96G78
PDB IDs		1WF0 2CQG	2CPR 3SAF 3SAG 3SAH
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Oxidative Stress Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Histone H2A-K119 Monoubiquitination Cellular Macromolecule Catabolic Process Transcription, DNA-templated Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Collateral Sprouting In Absence Of Injury Regulation Of Transcription, DNA-templated RNA Phosphodiester Bond Hydrolysis Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process RRNA Processing Collateral Sprouting Axon Midline Choice Point Recognition Growth RRNA Metabolic Process Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Peptidase Activity Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Transcription, DNA-templated Cell Growth	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Deamination RNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis Gene Expression Maturation Of 5.8S RRNA Histone MRNA Catabolic Process RRNA Catabolic Process Cellular Metabolic Process DNA Modification Protein K63-linked Deubiquitination Histone Deubiquitination Histone MRNA Metabolic Process DNA Metabolic Process Chromatin Modification Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Male Germ Cell Proliferation Metabolic Process Chromatin Remodeling MRNA Processing Regulation Of RNA Stability Chromatin Organization Thrombopoietin-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Histone H2A K63-linked Deubiquitination Regulation Of Male Germ Cell Proliferation Endomitotic Cell Cycle
Tagcloud ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	18s adopt assumed candidates carry defects exosome extensively functionally fundamental hela homolog its2 itss nucleolar polycistronic posing precede precursors processing recruit ribosomopathies rnas rrna rrnas rrp6 spacers transcribed yeast
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	18s adopt assumed candidates carry defects exosome extensively functionally fundamental hela homolog its2 itss nucleolar polycistronic posing precede precursors processing recruit ribosomopathies rnas rrna rrnas rrp6 spacers transcribed yeast
Tagcloud (Intersection) ?