TARDBP and EXOSC10

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TARDBP	EXOSC10
Description		TAR DNA binding protein	exosome component 10
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small-subunit Processome Nucleolar Exosome (RNase Complex)
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Lipid Binding Identical Protein Binding Pre-mRNA Intronic Binding Molecular Condensate Scaffold Activity	Nucleotide Binding 3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity Metal Ion Binding Telomerase RNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization Amyloid Fibril Formation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair RRNA Processing RNA Processing RNA Catabolic Process DNA Damage Response Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosomal Small Subunit Biogenesis Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		18 interacting genes: APP ARHGEF28 EXOSC10 FBXO7 IRAK2 LONRF2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF126 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	40 interacting genes: ALDH1B1 B9D1 CEBPA CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIC2 SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 USP36 USP7 XRN1 XRN2
Entrez ID		23435	5394
HPRD ID		05466	16180
Ensembl ID		ENSG00000120948	ENSG00000171824
Uniprot IDs		Q13148 Q9H256	Q01780
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B 7KWZ 7N9H 7PY2 7Q3U 8A6I 8CG3 8CGG 8CGH 8QX9 8QXA 8QXB 9FOF 9FOR	2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R 7MQA
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Heterodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Ubiquitin Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Ubiquitin Ligase Complex Negative Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process MRNA Catabolic Process Protein Ubiquitination Protein Catabolic Process 3'-5'-RNA Exonuclease Activity Regulation Of Metabolic Process Catabolic Process Zinc Ion Binding Ubiquitin Protein Ligase Activity Aggresome Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Cytoplasm Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Regulation Of Macromolecule Metabolic Process RNA Catabolic Process Exonuclease Activity	Nuclear MRNA Surveillance MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear RNA Surveillance RNA Catabolic Process RNA Surveillance Cytoplasmic Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) MRNA Metabolic Process RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Exoribonuclease Complex SnRNA 3'-end Processing RNA Metabolic Process RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Negative Regulation Of Gene Expression RRNA Processing Macromolecule Metabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing 5'-3' Exonuclease Activity Macromolecule Catabolic Process RNA Processing DNA Deamination Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Exonuclease Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleolus Sno(s)RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 5'-3' RNA Exonuclease Activity MRNA 3'-UTR AU-rich Region Binding DNA Modification Cysteine-type Deubiquitinase Activity
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