TARDBP and GNB2L1

Number of citations of the paper that reports this interaction (PMID 24825905)
0

Data Source:
BioGRID (two hybrid)

		TARDBP	GNB2L1
Gene Name		TAR DNA binding protein	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Nuclear Speck Interchromatin Granule	Phagocytic Cup Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Kinase C Binding Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Protein Complex Scaffold SH2 Domain Binding Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Stabilization	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of CAMP Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Homooligomerization Regulation Of Protein Localization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		16 interactors: APP EXOSC10 FUS GNB2L1 IRAK2 LSM6 MED6 NACC1 NSFL1C RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	86 interactors: ADH1B ADRB2 AGTRAP AR AURKB BCL2L11 CCNA1 CDKN1A CHERP CSF2RB DDX19B DGCR14 DNM1 DYNLL1 EIF6 EPOR FBXW7 FYN GABRB3 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IFNR IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MKRN2 NFATC1 NR3C1 NSMAF PABPC1 PDE4D PLCG1 PLEC PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TCEB1 TCEB2 TNFRSF1A TP63 TP73 TSC22D4 TUBB TYK2 WDR83
Entrez ID		23435	10399
HPRD ID		05466	01503
Ensembl ID			ENSG00000204628
Uniprot IDs		B1AKP7 B4DJ45 Q13148 Q9H256	E9KL35 P63244
PDB IDs		1WF0 2CQG	3J3A 4AOW
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Oxidative Stress Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Histone H2A-K119 Monoubiquitination Cellular Macromolecule Catabolic Process Transcription, DNA-templated Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Collateral Sprouting In Absence Of Injury Regulation Of Transcription, DNA-templated RNA Phosphodiester Bond Hydrolysis Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process RRNA Processing Collateral Sprouting Axon Midline Choice Point Recognition Growth RRNA Metabolic Process Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Peptidase Activity Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Transcription, DNA-templated Cell Growth	Signaling Cell Communication Cellular Response To Stimulus Signal Transduction Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Response To External Stimulus Defense Response Viral Process Response To Stress Immune System Process Regulation Of Immune Response Regulation Of Body Fluid Levels Regulation Of Cell Proliferation Regulation Of Immune System Process Response To Abiotic Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Response To Cytokine Regulation Of Cell Death Regulation Of Cellular Process Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Platelet Activation Innate Immune Response Immune Response Regulation Of Phosphorylation Blood Coagulation Regulation Of Apoptotic Process Hemostasis Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transport Peptidyl-tyrosine Autophosphorylation Cellular Process Neurotrophin TRK Receptor Signaling Pathway Developmental Process Regulation Of Angiogenesis Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Intersection) ?