TARDBP and NSFL1C

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TARDBP	NSFL1C
Gene Name		TAR DNA binding protein	NSFL1 (p97) cofactor (p47)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Nuclear Speck Interchromatin Granule	Nucleoplasm Chromosome Cytoplasm Golgi Stack Cytosol Plasma Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Nucleotide Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Binding Lipid Binding Protein Phosphatase Type 1 Regulator Activity Ubiquitin Binding
	Biological Process	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Stabilization	Autophagic Vacuole Assembly Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Membrane Fusion
Pathways
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		16 interactors: APP EXOSC10 FUS GNB2L1 IRAK2 LSM6 MED6 NACC1 NSFL1C RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	14 interactors: ANP32A CDK1 DBI FAM32A GLMN GSK3B LIPE NGLY1 PHAX RPL22 SRP14 STX5 TARDBP VCP
Entrez ID		23435	55968
HPRD ID		05466	09425
Ensembl ID			ENSG00000088833
Uniprot IDs		B1AKP7 B4DJ45 Q13148 Q9H256	Q53FE8 Q9UNZ2
PDB IDs		1WF0 2CQG	1SS6
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Oxidative Stress Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Histone H2A-K119 Monoubiquitination Cellular Macromolecule Catabolic Process Transcription, DNA-templated Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Collateral Sprouting In Absence Of Injury Regulation Of Transcription, DNA-templated RNA Phosphodiester Bond Hydrolysis Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process RRNA Processing Collateral Sprouting Axon Midline Choice Point Recognition Growth RRNA Metabolic Process Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Peptidase Activity Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Transcription, DNA-templated Cell Growth	Cytoplasmic Transport Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Intracellular Transport Cellular Localization Positive Regulation Of Protein Transport Protein Localization Establishment Of Localization In Cell Cellular Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Transport Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Protein Localization Response To Endoplasmic Reticulum Stress Intracellular Protein Transport Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Transport Nucleocytoplasmic Transport Nuclear Transport Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteolysis Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Pronuclear Fusion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat Positive Regulation Of Transport Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Cell Differentiation Regulation Of Protein Localization Organelle Fusion Cellular Macromolecule Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development SnRNA Export From Nucleus Superior Temporal Gyrus Development Membrane Organization SRP-dependent Cotranslational Protein Targeting To Membrane Triglyceride Metabolic Process Cotranslational Protein Targeting To Membrane ER To Golgi Vesicle-mediated Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Neutral Lipid Metabolic Process Re-entry Into Mitotic Cell Cycle Golgi Disassembly Negative Regulation Of Neuron Maturation
Tagcloud ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?