TARDBP and LONRF2

Number of citations of the paper that reports this interaction (PubMedID 37474791)
0

Data Source:
BioGRID (pull down)

		TARDBP	LONRF2
Description		TAR DNA binding protein	LON peptidase N-terminal domain and ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule	Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Lipid Binding Identical Protein Binding Pre-mRNA Intronic Binding Molecular Condensate Scaffold Activity	Protein Binding Zinc Ion Binding Ribonucleoprotein Complex Binding Metal Ion Binding Misfolded Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization Amyloid Fibril Formation	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Spinal Cord Motor Neuron Differentiation Neuron Projection Development Negative Regulation Of Neuron Apoptotic Process Neuromuscular Process Neuron Apoptotic Process Motor Behavior
Pathways
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Asthma ( 34103634) Body mass index ( 29273807) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income ( 27818178 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Regular attendance at a religious group ( 29970889)
Interacting Genes		18 interacting genes: APP ARHGEF28 EXOSC10 FBXO7 IRAK2 LONRF2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF126 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	2 interacting genes: HNRNPM TARDBP
Entrez ID		23435	164832
HPRD ID		05466	13503
Ensembl ID		ENSG00000120948	ENSG00000170500
Uniprot IDs		Q13148 Q9H256	Q1L5Z9
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B 7KWZ 7N9H 7PY2 7Q3U 8A6I 8CG3 8CGG 8CGH 8QX9 8QXA 8QXB 9FOF 9FOR
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Heterodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Ubiquitin Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Ubiquitin Ligase Complex Negative Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process MRNA Catabolic Process Protein Ubiquitination Protein Catabolic Process 3'-5'-RNA Exonuclease Activity Regulation Of Metabolic Process Catabolic Process Zinc Ion Binding Ubiquitin Protein Ligase Activity Aggresome Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Cytoplasm Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Regulation Of Macromolecule Metabolic Process RNA Catabolic Process Exonuclease Activity	Nuclear Inner Membrane Organization MRNA Processing RNA Splicing Perichromatin Fibrils Interchromatin Granule Paraspeckles Nucleic Acid Binding MRNA Metabolic Process Host-mediated Suppression Of Viral Transcription Pre-mRNA Intronic Binding Host-mediated Suppression Of Viral Proces RNA Processing 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Alternative MRNA Splicing, Via Spliceosome Amyloid Fibril Formation Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Protein Import Into Nucleus
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