EXOSC10 and MPHOSPH6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, biochemical, cross-linking study)
HPRD (two hybrid)

		EXOSC10	MPHOSPH6
Description		exosome component 10	M-phase phosphoprotein 6
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small-subunit Processome Nucleolar Exosome (RNase Complex)	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding 3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity Metal Ion Binding Telomerase RNA Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair RRNA Processing RNA Processing RNA Catabolic Process DNA Damage Response Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosomal Small Subunit Biogenesis Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of MRNA Cis Splicing, Via Spliceosome	Maturation Of 5.8S RRNA RRNA Processing
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)	Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Seasonality and depression ( 30217971)
Interacting Genes		40 interacting genes: ALDH1B1 B9D1 CEBPA CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIC2 SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 USP36 USP7 XRN1 XRN2	28 interacting genes: AATF APLP1 ARHGAP18 CRYAA DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		5394	10200
HPRD ID		16180	16111
Ensembl ID		ENSG00000171824	ENSG00000135698
Uniprot IDs		Q01780	H3BNT4 Q99547
PDB IDs		2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R 7MQA	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear RNA Surveillance RNA Catabolic Process RNA Surveillance Cytoplasmic Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) MRNA Metabolic Process RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Exoribonuclease Complex SnRNA 3'-end Processing RNA Metabolic Process RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Negative Regulation Of Gene Expression RRNA Processing Macromolecule Metabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing 5'-3' Exonuclease Activity Macromolecule Catabolic Process RNA Processing DNA Deamination Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Exonuclease Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleolus Sno(s)RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 5'-3' RNA Exonuclease Activity MRNA 3'-UTR AU-rich Region Binding DNA Modification Cysteine-type Deubiquitinase Activity	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) 3'-5'-RNA Exonuclease Activity Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity SnRNA Metabolic Process MRNA Metabolic Process RNA 3'-end Processing RNA Catabolic Process RNA Binding Nuclear-transcribed MRNA Catabolic Process SnRNA Catabolic Process Nuclear RNA Surveillance CUT Catabolic Process RNA Surveillance Regulation Of Female Gonad Development Regulation Of Telomere Maintenance Via Telomerase RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Catabolic Process U4 SnRNA 3'-end Processing Identical Protein Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus RRNA 3'-end Processing Euchromatin TRNA Decay Nuclear MRNA Surveillance Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Telomerase RNA Localization To Cajal Body MDM2/MDM4 Family Protein Binding DNA Deamination Negative Regulation Of Metabolic Process Nucleobase-containing Compound Catabolic Process Response To Heat Regulation Of DNA Biosynthetic Process RRNA Processing Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA Regulation Of Cell Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Apoptotic Process
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