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EXOSC10 and EXOSC8
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
EXOSC10
EXOSC8
Gene Name
exosome component 10
exosome component 8
Image
Gene Ontology Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Membrane
Transcriptionally Active Chromatin
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Exoribonuclease Activity
Protein Binding
3'-5' Exonuclease Activity
Poly(A) RNA Binding
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
Dosage Compensation By Inactivation Of X Chromosome
Nuclear MRNA Surveillance
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Histone MRNA Catabolic Process
Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Biological_process
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
35 interactors:
ALDH1B1
B9D1
CHPF
CIB1
DIS3
DXO
EIF3M
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
FERMT3
FOXRED1
IMMT
LCAT
LSM2
LSM8
MPHOSPH6
MPP6
NOMO1
NOMO2
PTGES2
RPE
RUVBL2
SCRIB
SKIV2L
SSRP1
TARDBP
TOX4
UPF2
USP16
USP21
XRN1
XRN2
42 interactors:
AEN
ATF2
COL23A1
COX5A
CRMP1
CWC22
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM90A1
FHOD1
FOXN3
FRG1
LSM1
LSM7
MKRN1
MORN4
MPP6
OTUD4
RASSF1
REL
RPP14
SKIV2L2
SNRPC
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP6
XRN1
XRN2
ZFP36
Entrez ID
5394
11340
HPRD ID
16180
09351
Ensembl ID
ENSG00000171824
ENSG00000120699
Uniprot IDs
Q01780
Q96G78
Q96B26
PDB IDs
2CPR
3SAF
3SAG
3SAH
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
Aromatic Compound Catabolic Process
Cellular Macromolecule Catabolic Process
Ribosome Biogenesis
Ribonucleoprotein Complex Biogenesis
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Catabolic Process
RNA Metabolic Process
NcRNA Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nuclear MRNA Surveillance
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Deamination
RNA Surveillance
Nucleic Acid Phosphodiester Bond Hydrolysis
RNA Phosphodiester Bond Hydrolysis
Gene Expression
Maturation Of 5.8S RRNA
Histone MRNA Catabolic Process
RRNA Catabolic Process
Cellular Metabolic Process
DNA Modification
Protein K63-linked Deubiquitination
Histone Deubiquitination
Histone MRNA Metabolic Process
DNA Metabolic Process
Chromatin Modification
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Male Germ Cell Proliferation
Metabolic Process
Chromatin Remodeling
MRNA Processing
Regulation Of RNA Stability
Chromatin Organization
Thrombopoietin-mediated Signaling Pathway
Posttranscriptional Regulation Of Gene Expression
Histone H2A K63-linked Deubiquitination
Regulation Of Male Germ Cell Proliferation
Endomitotic Cell Cycle
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Ribosome Biogenesis
Aromatic Compound Catabolic Process
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
RNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
DNA Deamination
Histone MRNA Catabolic Process
RNA Processing
Cellular Metabolic Process
Histone MRNA Metabolic Process
MRNA Processing
Intracellular MRNA Localization
Metabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
DNA Modification
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RNA Splicing
SnoRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
Tagcloud
?
18s
adopt
assumed
candidates
carry
defects
exosome
extensively
functionally
fundamental
hela
homolog
its2
itss
nucleolar
polycistronic
posing
precede
precursors
processing
recruit
ribosomopathies
rnas
rrna
rrnas
rrp6
spacers
transcribed
yeast
Tagcloud (Difference)
?
18s
adopt
assumed
candidates
carry
defects
exosome
extensively
functionally
fundamental
hela
homolog
its2
itss
nucleolar
polycistronic
posing
precede
precursors
processing
recruit
ribosomopathies
rnas
rrna
rrnas
rrp6
spacers
transcribed
yeast
Tagcloud (Intersection)
?