TARDBP and IRAK2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TARDBP	IRAK2
Gene Name		TAR DNA binding protein	interleukin-1 receptor-associated kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Nuclear Speck Interchromatin Granule	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Stabilization	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways			IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		16 interactors: APP EXOSC10 FUS GNB2L1 IRAK2 LSM6 MED6 NACC1 NSFL1C RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	20 interactors: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A
Entrez ID		23435	3656
HPRD ID		05466	04491
Ensembl ID			ENSG00000134070
Uniprot IDs		B1AKP7 B4DJ45 Q13148 Q9H256	O43187
PDB IDs		1WF0 2CQG	3MOP
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Oxidative Stress Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Histone H2A-K119 Monoubiquitination Cellular Macromolecule Catabolic Process Transcription, DNA-templated Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Collateral Sprouting In Absence Of Injury Regulation Of Transcription, DNA-templated RNA Phosphodiester Bond Hydrolysis Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process RRNA Processing Collateral Sprouting Axon Midline Choice Point Recognition Growth RRNA Metabolic Process Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Peptidase Activity Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Transcription, DNA-templated Cell Growth	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Lipopolysaccharide Response To Bacterium Regulation Of Interleukin-6 Production Regulation Of Immune System Process Response To Molecule Of Bacterial Origin Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Toll Signaling Pathway Immune Response Response To Other Organism Defense Response Interleukin-1-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Biotic Stimulus Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Signaling Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Signal Transduction Immune System Process Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Lipopolysaccharide Signal Transduction
Tagcloud ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	adapter bmdm bmdms catalytically corrected d359a e525a hardly il10 il6 irak1 knock limiting modest myd88 pdcs plasmacytoid secretion sustain tlr tlr4 tlr7 tlr9 tnfa tnfr toll traf6 trif
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	adapter bmdm bmdms catalytically corrected d359a e525a hardly il10 il6 irak1 knock limiting modest myd88 pdcs plasmacytoid secretion sustain tlr tlr4 tlr7 tlr9 tnfa tnfr toll traf6 trif
Tagcloud (Intersection) ?