EXOSC10 and NOMO2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		EXOSC10	NOMO2
Description		exosome component 10	NODAL modulator 2
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small-subunit Processome Nucleolar Exosome (RNase Complex)	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Multi-pass Translocon Complex
	Molecular Function	Nucleotide Binding 3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity Metal Ion Binding Telomerase RNA Binding	Protein Binding Carbohydrate Binding Ribosome Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair RRNA Processing RNA Processing RNA Catabolic Process DNA Damage Response Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosomal Small Subunit Biogenesis Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of MRNA Cis Splicing, Via Spliceosome	Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)	Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		40 interacting genes: ALDH1B1 B9D1 CEBPA CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIC2 SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 USP36 USP7 XRN1 XRN2	4 interacting genes: DSCAM EXOSC10 STAT1 UBE3A
Entrez ID		5394	283820
HPRD ID		16180	12375
Ensembl ID		ENSG00000171824	ENSG00000185164
Uniprot IDs		Q01780	Q5JPE7
PDB IDs		2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R 7MQA	9C7U 9C7V
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear RNA Surveillance RNA Catabolic Process RNA Surveillance Cytoplasmic Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) MRNA Metabolic Process RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Exoribonuclease Complex SnRNA 3'-end Processing RNA Metabolic Process RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Negative Regulation Of Gene Expression RRNA Processing Macromolecule Metabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing 5'-3' Exonuclease Activity Macromolecule Catabolic Process RNA Processing DNA Deamination Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Exonuclease Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleolus Sno(s)RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 5'-3' RNA Exonuclease Activity MRNA 3'-UTR AU-rich Region Binding DNA Modification Cysteine-type Deubiquitinase Activity	Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Metabolic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome CUT Catabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Interleukin-7-mediated Signaling Pathway ISGF3 Complex Interleukin-27-mediated Signaling Pathway Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal Cell Differentiation Involved In Kidney Development Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cellular PH Reduction Regulation Of Golgi Lumen Acidification Netrin-activated Signaling Pathway RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cell Proliferation Involved In Kidney Development Prostate Gland Growth TRNA Decay Nuclear MRNA Surveillance Regulation Of Telomerase RNA Localization To Cajal Body Regulation Of Nephron Tubule Epithelial Cell Differentiation Progesterone Receptor Signaling Pathway Camera-type Eye Photoreceptor Cell Differentiation Axon
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