TARDBP and ARHGEF28

Number of citations of the paper that reports this interaction (PubMedID 38739752)
77

Data Source:
BioGRID (protein complementation assay)

		TARDBP	ARHGEF28
Description		TAR DNA binding protein	Rho guanine nucleotide exchange factor 28
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Lipid Binding Identical Protein Binding Pre-mRNA Intronic Binding Molecular Condensate Scaffold Activity	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization Amyloid Fibril Formation	Cell Morphogenesis Central Nervous System Neuron Axonogenesis Cell Differentiation Regulation Of Rho Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Neurofilament Cytoskeleton Organization
Pathways			EPHB-mediated forward signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Age-related hearing impairment ( 34108613) Chin dimples ( 27182965) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol ( 30275531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hodgkin's lymphoma ( 34216518) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Vaginal microbiome composition (Shannon diversity index) ( 32723796) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		18 interacting genes: APP ARHGEF28 EXOSC10 FBXO7 IRAK2 LONRF2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF126 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	8 interacting genes: AKT1 CTAG1A CTAG1B MAPK8IP1 RHOA TARDBP YWHAE YWHAH
Entrez ID		23435	64283
HPRD ID		05466	15244
Ensembl ID		ENSG00000120948	ENSG00000214944
Uniprot IDs		Q13148 Q9H256	Q8N1W1
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B 7KWZ 7N9H 7PY2 7Q3U 8A6I 8CG3 8CGG 8CGH 8QX9 8QXA 8QXB 9FOF 9FOR	6BC0 6BC1
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Heterodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Ubiquitin Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Ubiquitin Ligase Complex Negative Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process MRNA Catabolic Process Protein Ubiquitination Protein Catabolic Process 3'-5'-RNA Exonuclease Activity Regulation Of Metabolic Process Catabolic Process Zinc Ion Binding Ubiquitin Protein Ligase Activity Aggresome Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Cytoplasm Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Regulation Of Macromolecule Metabolic Process RNA Catabolic Process Exonuclease Activity	Intracellular Receptor Signaling Pathway Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation Protein Localization To Endoplasmic Reticulum Regulation Of Phosphorylation Identical Protein Binding TRNA Threonylcarbamoyladenosine Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway TRNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Modification Process Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Sodium Ion Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Migration Regulation Of Metal Ion Transport Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of TRNA Methylation Golgi To Plasma Membrane Transport Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Positive Regulation Of Nucleocytoplasmic Transport Glucocorticoid Catabolic Process Dentate Gyrus Mossy Fiber Nuclear Inner Membrane Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Regulation Of T Cell Activation RNA Stabilization Enzyme Binding Negative Regulation Of RNA Catabolic Process Positive Regulation Of Organelle Assembly Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Protein Kinase Binding Response To Heat Cytoplasm Regulation Of Neuron Projection Development Negative Regulation Of Protein Localization To Lysosome Endothelial Cell Migration
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