TARDBP and XRN2

Number of citations of the paper that reports this interaction (PMID 20020773)
65

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		TARDBP	XRN2
Gene Name		TAR DNA binding protein	5-3 exoribonuclease 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Nuclear Speck Interchromatin Granule	Nucleus Nucleolus Membrane Aggresome
	Molecular Function	Nucleotide Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Transcription Termination Site Sequence-specific DNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Zinc Ion Binding 5'-3' Exonuclease Activity Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Stabilization	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis Cell Growth RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		16 interactors: APP EXOSC10 FUS GNB2L1 IRAK2 LSM6 MED6 NACC1 NSFL1C RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	24 interactors: ALDH1B1 ATRN COMT CSNK2A1 CTSC DISC1 DXO EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 TARDBP TIPARP TOLLIP UPF2
Entrez ID		23435	22803
HPRD ID		05466	10309
Ensembl ID			ENSG00000088930
Uniprot IDs		B1AKP7 B4DJ45 Q13148 Q9H256	Q9H0D6
PDB IDs		1WF0 2CQG
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Oxidative Stress Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Histone H2A-K119 Monoubiquitination Cellular Macromolecule Catabolic Process Transcription, DNA-templated Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Collateral Sprouting In Absence Of Injury Regulation Of Transcription, DNA-templated RNA Phosphodiester Bond Hydrolysis Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process RRNA Processing Collateral Sprouting Axon Midline Choice Point Recognition Growth RRNA Metabolic Process Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Peptidase Activity Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Transcription, DNA-templated Cell Growth	Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear MRNA Surveillance Translational Elongation RNA Surveillance Catabolic Process Regulation Of Protein Catabolic Process Translation Cellular Metabolic Process Translational Initiation RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Nuclear Export Ribonucleoprotein Complex Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Metabolic Process Estrogen Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process RNA Localization Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Ribosome Biogenesis Regulation Of Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Homocysteine Metabolic Process TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Cellular Response To Phosphate Starvation Negative Regulation Of Potassium Ion Export Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Cellular Protein Metabolic Process Regulation Of Homocysteine Metabolic Process Protein Adenylylation Regulation Of Heart Rate By Hormone
Tagcloud ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met	8s arabidopsis at1g52930 at3g15460 atbrx1 biogenesis brx1 bypassed ets eukaryotes export implying intermediates its1 leaves nucleolus orthologs plant pointed processing rbfs ribosomal ribosome rrna spacer steps thaliana transcribed ubiquitously
Tagcloud (Intersection) ?