Wiki-Pi
About
Search
People
Updates
Search
TARDBP
Description
TAR DNA binding protein
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Perichromatin Fibrils
Cytoplasm
Mitochondrion
Cytoplasmic Stress Granule
Nuclear Speck
Interchromatin Granule
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Nucleic Acid Binding
DNA Binding
Double-stranded DNA Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Lipid Binding
Identical Protein Binding
Pre-mRNA Intronic Binding
Molecular Condensate Scaffold Activity
Biological Process
Negative Regulation Of Protein Phosphorylation
MRNA Processing
RNA Splicing
Gene Expression
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Protein Stability
Positive Regulation Of Insulin Secretion
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Regulation Of Apoptotic Process
Host-mediated Suppression Of Viral Transcription
Rhythmic Process
Regulation Of Cell Cycle
3'-UTR-mediated MRNA Destabilization
3'-UTR-mediated MRNA Stabilization
Nuclear Inner Membrane Organization
Amyloid Fibril Formation
Pathways
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Beard thickness (
26926045
)
Ewing sarcoma (
22327514
)
Male-pattern baldness (
22693459
28196072
)
Novel Interacting Genes
1 novel interacting genes:
FCGR2A
Interacting Genes
18 interacting genes:
APP
ARHGEF28
EXOSC10
FBXO7
IRAK2
LONRF2
LSM6
MED6
NACC1
NSFL1C
RACK1
RNF126
RNF2
SETDB1
UBQLN1
XRN2
ZFAND2B
ZHX1
Entrez ID
23435
HPRD ID
05466
Ensembl ID
ENSG00000120948
Uniprot IDs
Q13148
Q9H256
PDB IDs
1WF0
2CQG
2N2C
2N3X
2N4G
2N4H
2N4P
4BS2
4IUF
4Y00
4Y0F
5MDI
5MRG
5W50
5W52
5W7V
5WHN
5WHP
5WIA
5WIQ
5WKB
5WKD
5X4F
6B1G
6CF4
6CFH
6N37
6N3A
6N3B
6N3C
6T4B
7KWZ
7N9H
7PY2
7Q3U
8A6I
8CG3
8CGG
8CGH
8QX9
8QXA
8QXB
9FOF
9FOR
Enriched GO Terms of Interacting Partners
?
Macromolecule Catabolic Process
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Protein Heterodimerization Activity
Regulation Of Intrinsic Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Protein Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Response To Endoplasmic Reticulum Stress
Proteasomal Protein Catabolic Process
Ubiquitin Binding
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleus
Ubiquitin Ligase Complex
Negative Regulation Of Biosynthetic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
MRNA Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
3'-5'-RNA Exonuclease Activity
Regulation Of Metabolic Process
Catabolic Process
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Aggresome
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Amyloid-beta Complex
Growth Cone Lamellipodium
Negative Regulation Of Gene Expression
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Signaling Pathway
Cytoplasm
Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Negative Regulation Of Store-operated Calcium Channel Activity
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Macromolecule Metabolic Process
RNA Catabolic Process
Exonuclease Activity
Tagcloud
?