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EXOSC10 and EXOSC5
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
EXOSC10
EXOSC5
Gene Name
exosome component 10
exosome component 5
Image
Gene Ontology Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Membrane
Transcriptionally Active Chromatin
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
Nucleotide Binding
Exoribonuclease Activity
Protein Binding
3'-5' Exonuclease Activity
Poly(A) RNA Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
Dosage Compensation By Inactivation Of X Chromosome
Nuclear MRNA Surveillance
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Histone MRNA Catabolic Process
Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
35 interactors:
ALDH1B1
B9D1
CHPF
CIB1
DIS3
DXO
EIF3M
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
FERMT3
FOXRED1
IMMT
LCAT
LSM2
LSM8
MPHOSPH6
MPP6
NOMO1
NOMO2
PTGES2
RPE
RUVBL2
SCRIB
SKIV2L
SSRP1
TARDBP
TOX4
UPF2
USP16
USP21
XRN1
XRN2
32 interactors:
BIRC2
CALCOCO2
CDK5RAP1
DHRS2
DIS3
DOCK8
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
GOLGA2
IKZF3
KIAA1217
KRT13
LIPG
LSM5
MPP6
NUP210
PA2G4
PKM
POLR2L
REL
SFPQ
SKIV2L2
TNFAIP1
TRIM54
ZNF558
Entrez ID
5394
56915
HPRD ID
16180
16222
Ensembl ID
ENSG00000171824
ENSG00000077348
Uniprot IDs
Q01780
Q96G78
M0R050
Q9NQT4
PDB IDs
2CPR
3SAF
3SAG
3SAH
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
Aromatic Compound Catabolic Process
Cellular Macromolecule Catabolic Process
Ribosome Biogenesis
Ribonucleoprotein Complex Biogenesis
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Catabolic Process
RNA Metabolic Process
NcRNA Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nuclear MRNA Surveillance
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Deamination
RNA Surveillance
Nucleic Acid Phosphodiester Bond Hydrolysis
RNA Phosphodiester Bond Hydrolysis
Gene Expression
Maturation Of 5.8S RRNA
Histone MRNA Catabolic Process
RRNA Catabolic Process
Cellular Metabolic Process
DNA Modification
Protein K63-linked Deubiquitination
Histone Deubiquitination
Histone MRNA Metabolic Process
DNA Metabolic Process
Chromatin Modification
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Male Germ Cell Proliferation
Metabolic Process
Chromatin Remodeling
MRNA Processing
Regulation Of RNA Stability
Chromatin Organization
Thrombopoietin-mediated Signaling Pathway
Posttranscriptional Regulation Of Gene Expression
Histone H2A K63-linked Deubiquitination
Regulation Of Male Germ Cell Proliferation
Endomitotic Cell Cycle
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
NcRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RNA Metabolic Process
Maturation Of 5.8S RRNA
Nuclear MRNA Surveillance
Aromatic Compound Catabolic Process
RNA Surveillance
Cellular Macromolecule Catabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
Nucleic Acid Phosphodiester Bond Hydrolysis
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
RNA Processing
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
Cellular Metabolic Process
RNA Localization
DNA Deamination
Immune System Process
Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Immune Response
Leukocyte Activation
Isotype Switching
Tagcloud
?
18s
adopt
assumed
candidates
carry
defects
exosome
extensively
functionally
fundamental
hela
homolog
its2
itss
nucleolar
polycistronic
posing
precede
precursors
processing
recruit
ribosomopathies
rnas
rrna
rrnas
rrp6
spacers
transcribed
yeast
Tagcloud (Difference)
?
18s
adopt
assumed
candidates
carry
defects
exosome
extensively
functionally
fundamental
hela
homolog
its2
itss
nucleolar
polycistronic
posing
precede
precursors
processing
recruit
ribosomopathies
rnas
rrna
rrnas
rrp6
spacers
transcribed
yeast
Tagcloud (Intersection)
?