EXOSC10 and PTGES2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EXOSC10	PTGES2
Gene Name		exosome component 10	prostaglandin E synthase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Transcriptionally Active Chromatin	Golgi Membrane Nucleus Mitochondrion Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Exoribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Poly(A) RNA Binding	DNA Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Lyase Activity Heme Binding Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Prostaglandin Biosynthetic Process Cell Redox Homeostasis Positive Regulation Of Transcription, DNA-templated Secretion Oxidation-reduction Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 MPP6 NOMO1 NOMO2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 TARDBP TOX4 UPF2 USP16 USP21 XRN1 XRN2	4 interactors: C1orf189 CEBPB EXOSC10 PTGFR
Entrez ID		5394	80142
HPRD ID		16180	07458
Ensembl ID		ENSG00000171824	ENSG00000148334
Uniprot IDs		Q01780 Q96G78	A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs		2CPR 3SAF 3SAG 3SAH
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Deamination RNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis Gene Expression Maturation Of 5.8S RRNA Histone MRNA Catabolic Process RRNA Catabolic Process Cellular Metabolic Process DNA Modification Protein K63-linked Deubiquitination Histone Deubiquitination Histone MRNA Metabolic Process DNA Metabolic Process Chromatin Modification Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Male Germ Cell Proliferation Metabolic Process Chromatin Remodeling MRNA Processing Regulation Of RNA Stability Chromatin Organization Thrombopoietin-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Histone H2A K63-linked Deubiquitination Regulation Of Male Germ Cell Proliferation Endomitotic Cell Cycle	Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Cellular Response To Acid Chemical Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Response To Bacterium Intracellular MRNA Localization Dosage Compensation RRNA Catabolic Process Calcium-mediated Signaling Using Intracellular Calcium Source Maturation Of 5.8S RRNA Parturition Cellular Response To Prostaglandin Stimulus Histone MRNA Metabolic Process Response To Other Organism Regulation Of Interleukin-6 Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Response To Biotic Stimulus Response To Lipid RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Acute-phase Response Negative Regulation Of Cell Death Brown Fat Cell Differentiation Cellular Response To Fatty Acid Positive Regulation Of Fat Cell Differentiation Cellular Response To Amino Acid Stimulus Reproductive Process Response To Fatty Acid Positive Regulation Of Osteoblast Differentiation Acute Inflammatory Response Regulation Of Apoptotic Process Epithelial Cell Proliferation Calcium-mediated Signaling Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Death Positive Regulation Of Ossification Mammary Gland Epithelium Development Regulation Of Interleukin-6 Production RNA Phosphodiester Bond Hydrolysis Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		18s adopt assumed candidates carry defects exosome extensively functionally fundamental hela homolog its2 itss nucleolar polycistronic posing precede precursors processing recruit ribosomopathies rnas rrna rrnas rrp6 spacers transcribed yeast
Tagcloud (Difference) ?		18s adopt assumed candidates carry defects exosome extensively functionally fundamental hela homolog its2 itss nucleolar polycistronic posing precede precursors processing recruit ribosomopathies rnas rrna rrnas rrp6 spacers transcribed yeast
Tagcloud (Intersection) ?