TARDBP and MED6

Number of citations of the paper that reports this interaction (PMID 24825905)
0

Data Source:
BioGRID (two hybrid)

		TARDBP	MED6
Gene Name		TAR DNA binding protein	mediator complex subunit 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Nuclear Speck Interchromatin Granule	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding
	Biological Process	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Stabilization	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		16 interactors: APP EXOSC10 FUS GNB2L1 IRAK2 LSM6 MED6 NACC1 NSFL1C RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	15 interactors: BCL6 CTDP1 ESR1 ESR2 MED25 MED8 MED9 PARP1 RARA SMAD1 SMAD2 SMARCA4 SREBF1 SUZ12 TARDBP
Entrez ID		23435	10001
HPRD ID		05466	04284
Ensembl ID			ENSG00000133997
Uniprot IDs		B1AKP7 B4DJ45 Q13148 Q9H256	O75586
PDB IDs		1WF0 2CQG
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Oxidative Stress Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Histone H2A-K119 Monoubiquitination Cellular Macromolecule Catabolic Process Transcription, DNA-templated Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Collateral Sprouting In Absence Of Injury Regulation Of Transcription, DNA-templated RNA Phosphodiester Bond Hydrolysis Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Aromatic Compound Catabolic Process Regulation Of RNA Metabolic Process RRNA Processing Collateral Sprouting Axon Midline Choice Point Recognition Growth RRNA Metabolic Process Cellular Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Peptidase Activity Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Transcription, DNA-templated Cell Growth	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Intracellular Estrogen Receptor Signaling Pathway Organ Growth Regulation Of Binding Positive Regulation Of Metabolic Process Positive Regulation Of Binding Regulation Of Cell Proliferation Tissue Morphogenesis Negative Regulation Of Cell Proliferation Urogenital System Development Cellular Response To Organic Cyclic Compound Cellular Metabolic Process Primary MiRNA Processing Epithelial Cell Development Regulation Of Gene Expression, Epigenetic
Tagcloud ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem c9orf72 causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous val14met
Tagcloud (Intersection) ?