PLAT and SERPINI1

Number of citations of the paper that reports this interaction (PubMedID 12228252)
0

Data Source:
HPRD (in vitro, in vivo)

		PLAT	SERPINI1
Description		plasminogen activator, tissue type	serpin family I member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasmic Vesicle Secretory Granule Lumen Neuronal Cell Body Perikaryon Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Central Nervous System Development Peripheral Nervous System Development Positive Regulation Of Neuron Projection Development
Pathways		Signaling by PDGF Dissolution of Fibrin Clot
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Eye color (saturation) ( 30664655) Fast beta electroencephalogram ( 28070124) Heart rate ( 23534349) Height ( 18391951) Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655)
Interacting Genes		28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1	3 interacting genes: PLAT PLG TSC2
Entrez ID		5327	5274
HPRD ID		01419	03901
Ensembl ID		ENSG00000104368	ENSG00000163536
Uniprot IDs		B4DN26 P00750	A0A0S2Z455 Q99574
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ	3F02 3F5N 3FGQ
Enriched GO Terms of Interacting Partners?		Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding	Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Fibrinolysis Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Schaffer Collateral - CA1 Synapse Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Wound Healing Serine-type Endopeptidase Activity Regulation Of Response To Wounding Protein Processing TSC1-TSC2 Complex Positive Regulation Of Fibrinolysis Prevention Of Polyspermy Serine Protease Inhibitor Complex Regulation Of Body Fluid Levels Protein Maturation Trans-synaptic Signaling Negative Regulation Of Plasminogen Activation Synaptic Signaling Signaling Receptor Binding Protein Antigen Binding Extracellular Matrix Regulation Of Fertilization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Plasminogen Activation Peptidase Activity Negative Regulation Of Mitophagy Anoikis Smooth Muscle Cell Migration Modulation Of Chemical Synaptic Transmission Trophoblast Giant Cell Differentiation Regulation Of Plasminogen Activation Apolipoprotein Binding Glutamatergic Synapse Negative Regulation Of Protein Metabolic Process Labyrinthine Layer Blood Vessel Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?