PLAT and LAMA1

Number of citations of the paper that reports this interaction (PubMedID 8360181)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PLAT	LAMA1
Description		plasminogen activator, tissue type	laminin subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Laminin Complex Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding
	Biological Process	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Tissue Development Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa	Lanoteplase
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455 30054458 30297969 32499647)
Interacting Genes		28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1	23 interacting genes: ACHE APCS APP C3 COL18A1 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TGM2 TMPRSS6 UBC USP7
Entrez ID		5327	284217
HPRD ID		01419	01033
Ensembl ID		ENSG00000104368	ENSG00000101680
Uniprot IDs		B4DN26 P00750	P25391
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?		Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding	Extracellular Exosome Laminin Binding Basement Membrane Extracellular Matrix Extracellular Region Cell Surface Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Binding Involved In Cell-matrix Adhesion Cell Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Collagen Binding Cell-substrate Adhesion Integrin Alpha1-beta1 Complex High-density Lipoprotein Particle Integrin Alpha2-beta1 Complex Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Cell Adhesion Integrin Complex Response To Muscle Activity Calcium Ion Binding Trans-synaptic Signaling By BDNF Basement Membrane Organization Focal Adhesion Acute-phase Response Peptidase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission Regulation Of Wound Healing Modulation Of Chemical Synaptic Transmission Endoplasmic Reticulum Lumen Laminin-1 Binding Positive Regulation Of Cell Adhesion Integrin Binding Serine-type Endopeptidase Activity Inflammatory Response Regulation Of Apoptotic Cell Clearance Regulation Of Response To Wounding Acute Inflammatory Response Positive Regulation Of Wound Healing Proteolysis Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Wound Healing Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Communication
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