PLAT and PDGFC

Number of citations of the paper that reports this interaction (PubMedID 22035541)
53

Data Source:
BioGRID (enzymatic study)

		PLAT	PDGFC
Description		plasminogen activator, tissue type	platelet derived growth factor C
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Central Nervous System Development Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Cell Migration Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by PDGF Dissolution of Fibrin Clot
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 34074324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypospadias ( 25108383) Immature fraction of reticulocytes ( 32888494) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 29317602) Monocyte count ( 32888494) Motor coordination ( 34177493) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 30578418) Speech perception in dyslexia ( 19786962) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418 30224653) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)
Interacting Genes		28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1	5 interacting genes: PDGFRA PLAT PLAU ST14 SUMO1
Entrez ID		5327	56034
HPRD ID		01419	10529
Ensembl ID		ENSG00000104368	ENSG00000145431
Uniprot IDs		B4DN26 P00750	Q9NRA1
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?		Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding	Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Serine Protease Inhibitor Complex Negative Regulation Of Plasminogen Activation Plasminogen Activation Serine-type Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Wound Healing Smooth Muscle Cell Migration Serine-type Endopeptidase Activity Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Response To Wounding Fibrinolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Muscle Cell Migration Positive Regulation Of Coagulation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Zymogen Activation External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Protein Processing Regulation Of Protein Maturation Protein Metabolic Process Positive Regulation Of Wound Healing Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Roof Of Mouth Development Platelet-derived Growth Factor Alpha-receptor Activity Coagulation Blood Coagulation Hemostasis Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Receptor-ligand Complex Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Proteolysis Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Epithelial Cell Morphogenesis Involved In Placental Branching
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