PLAT and KRT8

Number of citations of the paper that reports this interaction (PubMedID 9988531)
0

Data Source:
HPRD (in vitro, in vivo)

		PLAT	KRT8
Description		plasminogen activator, tissue type	keratin 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding	Protein Binding Scaffold Protein Binding
	Biological Process	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Tumor Necrosis Factor-mediated Signaling Pathway Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa	Tenecteplase Lanoteplase Copper
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Opioid dependence (time to event) ( 34124712) Prostate cancer ( 21743057) Sick sinus syndrome ( 33580673)
Interacting Genes		28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1	53 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KIFC3 KPNA2 KRT13 KRT15 KRT16 KRT18 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 OGT PIWIL2 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2
Entrez ID		5327	3856
HPRD ID		01419	01015
Ensembl ID		ENSG00000104368	ENSG00000170421
Uniprot IDs		B4DN26 P00750	P05787 Q7L4M3
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ	7K3C 7K3X 7K3Y
Enriched GO Terms of Interacting Partners?		Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding	Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Epithelial Cell Differentiation Cytoskeleton Organization Cytoskeleton Supramolecular Fiber Organization Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Organelle Organization Developmental Process Cytosol Extracellular Exosome MAP Kinase Activity Schwann Cell Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Desmosome ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Mechanical Stimulus Insulin-like Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Hair Cycle Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Tissue Development Structural Constituent Of Cytoskeleton Pseudopodium Protein Kinase Activity Interleukin-34-mediated Signaling Pathway Cornified Envelope Protein Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cyclase Activity Face Development Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development Regulation Of Golgi Inheritance Response To Muscle Stretch
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