NT5E and AFF1

Number of citations of the paper that reports this interaction (PubMedID 19956800)
58

Data Source:
BioGRID (two hybrid)

		NT5E	AFF1
Description		5'-nucleotidase ecto	ALF transcription elongation factor 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Side Of Membrane	Nucleus Transcription Elongation Factor Complex Super Elongation Complex
	Molecular Function	Nucleotide Binding 5'-deoxynucleotidase Activity Protein Binding 5'-nucleotidase Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Nucleotide Catabolic Process Response To ATP ADP Catabolic Process ATP Metabolic Process Adenosine Biosynthetic Process Negative Regulation Of Inflammatory Response Calcium Ion Homeostasis Inhibition Of Non-skeletal Tissue Mineralization	Regulation Of Gene Expression
Pathways		Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		Pentoxifylline
Diseases		Calcification of joints and arteries	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 27863252 32888494 29403010) Hematological and biochemical traits ( 31902109) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252 29403010) Mean corpuscular volume ( 32888494 27863252 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 32154731 30698716 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531 20686565 20864672 25961943) White blood cell count (basophil) ( 27863252 29403010)
Interacting Genes		6 interacting genes: ACTB AFF1 FN1 LAMA1 RNF24 ZNRF4	9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9
Entrez ID		4907	4299
HPRD ID		00552	08871
Ensembl ID		ENSG00000135318	ENSG00000172493
Uniprot IDs		P21589 Q6NZX3	B4DJU9 P51825 Q14C88
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6VC9 6VCA 6XUE 6XUG 6XUQ 6YE1 6YE2 6Z9B 6Z9D 7BBJ 7JV8 7JV9 7P9N 7P9R 7P9T 7PA4 7PB5 7PBA 7PBB 7PBY 7PCP 7PD9 7QGA 7QGL 7QGM 7QGO 8ZNZ	2LM0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Regulation Of Transepithelial Transport Blood Microparticle Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Negative Regulation Of Monocyte Activation Calcium-independent Cell-matrix Adhesion Basement Membrane Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Extracellular Matrix Structural Constituent Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Laminin-1 Complex Laminin-3 Complex Laminin Complex BBAF Complex Tat Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cell Adhesion Nitric-oxide Synthase Regulator Activity Cell-cell Junction Postsynaptic Actin Cytoskeleton Cell Adhesion Protein Localization To Adherens Junction Positive Regulation Of Cell Differentiation Dense Body Morphogenesis Of A Polarized Epithelium Establishment Or Maintenance Of Cell Polarity Osteoclast Development Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Neural Crest Cell Migration Involved In Autonomic Nervous System Development Super Elongation Complex Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Glycosphingolipid Binding Protein Complex Involved In Cell-matrix Adhesion Nitric-oxide Synthase Binding Cell Junction Assembly Transporter Activator Activity Endomembrane System Integrin Activation Negative Regulation Of Transforming Growth Factor Beta Production Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Branching Involved In Salivary Gland Morphogenesis	Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding
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