NT5E and AFF1

Number of citations of the paper that reports this interaction (PMID 19956800)
53

Data Source:
BioGRID (two hybrid)

		NT5E	AFF1
Gene Name		5-nucleotidase, ecto (CD73)	AF4/FMR2 family, member 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Transcription Elongation Factor Complex
	Molecular Function	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process AMP Catabolic Process Pyrimidine Nucleobase Metabolic Process DNA Metabolic Process Dephosphorylation Small Molecule Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response Nucleobase-containing Small Molecule Metabolic Process	Positive Regulation Of Transcription, DNA-templated
Pathways		Purine catabolism Pyrimidine catabolism Purine metabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs		Pentoxifylline
Diseases
GWAS		Metabolic traits ( 21886157)	Alzheimer's disease (cognitive decline) ( 23535033) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 22291604) Triglycerides ( 20864672 20686565)
Protein-Protein Interactions		4 interactors: ACTB AFF1 FN1 LAMA1	7 interactors: HIST3H3 MLLT1 MLLT3 NT5E SIAH1 SIAH2 SMAD9
Entrez ID		4907	4299
HPRD ID		00552	08871
Ensembl ID		ENSG00000135318	ENSG00000172493
Uniprot IDs		P21589 Q6NZX3	P51825 Q14C88
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I	2LM0
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Platelet Activation Cell Junction Assembly Cell Adhesion Locomotion Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Movement Of Cell Or Subcellular Component Generation Of Neurons Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Neurogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Establishment Of Monopolar Cell Polarity Cell Development Blood Coagulation Blood Vessel Morphogenesis Hemostasis Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Blood Vessel Development Axonogenesis Establishment Of Epithelial Cell Polarity Vasculature Development Axon Development Nervous System Development Regulation Of Body Fluid Levels Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Retina Vasculature Development In Camera-type Eye Anatomical Structure Morphogenesis Morphogenesis Of A Polarized Epithelium Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Activation Response To Wounding Branching Involved In Salivary Gland Morphogenesis Substantia Nigra Development Endodermal Cell Differentiation Platelet Aggregation Acute-phase Response Neuron Projection Development Positive Regulation Of Axon Extension Cell Projection Morphogenesis	Adenosine Biosynthetic Process AMP Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Purine Nucleoside Monophosphate Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mullerian Duct Regression Cellular Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Purine Ribonucleoside Catabolic Process Nucleobase-containing Compound Metabolic Process AMP Metabolic Process Adenosine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Segment Specification Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axon Guidance Anatomical Structure Regression Pyrimidine Nucleoside Catabolic Process Cellular Nitrogen Compound Metabolic Process Protein Destabilization Purine Ribonucleotide Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nitrogen Compound Metabolic Process
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa	abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa	abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Intersection) ?