NT5E and ATP6AP1

Data Source: HiPPIP (Novel)

		NT5E	ATP6AP1
Name		5'-nucleotidase ecto	ATPase H+ transporting accessory protein 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Side Of Membrane	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Endomembrane System Membrane Proton-transporting Two-sector ATPase Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase Complex Synapse Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	Nucleotide Binding 5'-deoxynucleotidase Activity Protein Binding 5'-nucleotidase Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding	ATPase Activator Activity Protein Binding Small GTPase Binding Transporter Activator Activity
	Biological Process	AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Nucleotide Catabolic Process Response To ATP ADP Catabolic Process ATP Metabolic Process Adenosine Biosynthetic Process Negative Regulation Of Inflammatory Response Calcium Ion Homeostasis Inhibition Of Non-skeletal Tissue Mineralization	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Cellular PH Osteoclast Development Cellular Response To Increased Oxygen Levels Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Endosome To Plasma Membrane Protein Transport Proton Transmembrane Transport
Pathways		Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection	Insulin receptor recycling RHOA GTPase cycle Transferrin endocytosis and recycling Ion channel transport
Drugs		Pentoxifylline	Tiludronic acid
Diseases		Calcification of joints and arteries	None
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Lung function ( 31902109 ) Metabolic traits ( 21886157 ) Serum metabolite levels ( 33031748 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ATP6AP1	5 novel interactors: ABCD1 CETN2 CTAG1B LARP1 NT5E
Interacting Genes		6 interacting genes: ACTB AFF1 FN1 LAMA1 RNF24 ZNRF4	6 interacting genes: ANG ERBB2 HBA1 NR1I2 OGT RHOU
Entrez ID		4907	537
HPRD ID		00552	02184
Ensembl ID		ENSG00000135318	ENSG00000071553
Uniprot IDs		P21589 Q6NZX3	A0A384MQW4 Q15904
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6VC9 6VCA 6XUE 6XUG 6XUQ 6YE1 6YE2 6Z9B 6Z9D 7BBJ 7JV8 7JV9 7P9N 7P9R 7P9T 7PA4 7PB5 7PBA 7PBB 7PBY 7PCP 7PD9 7QGA 7QGL 7QGM 7QGO 8ZNZ	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		Positive Regulation Of Cell Adhesion Regulation Of Transepithelial Transport Blood Microparticle Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Negative Regulation Of Monocyte Activation Calcium-independent Cell-matrix Adhesion Basement Membrane Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Extracellular Matrix Structural Constituent Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Laminin-1 Complex Laminin-3 Complex Laminin Complex BBAF Complex Tat Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cell Adhesion Nitric-oxide Synthase Regulator Activity Cell-cell Junction Postsynaptic Actin Cytoskeleton Cell Adhesion Protein Localization To Adherens Junction Positive Regulation Of Cell Differentiation Dense Body Morphogenesis Of A Polarized Epithelium Establishment Or Maintenance Of Cell Polarity Osteoclast Development Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Neural Crest Cell Migration Involved In Autonomic Nervous System Development Super Elongation Complex Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Glycosphingolipid Binding Protein Complex Involved In Cell-matrix Adhesion Nitric-oxide Synthase Binding Cell Junction Assembly Transporter Activator Activity Endomembrane System Integrin Activation Negative Regulation Of Transforming Growth Factor Beta Production Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Branching Involved In Salivary Gland Morphogenesis	Nucleobase-containing Compound Catabolic Process Sulfur Compound Transmembrane Transporter Activity Positive Regulation Of Lipid Biosynthetic Process Fatty-acyl-CoA Transport Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty-acyl-CoA Catabolic Process Amide Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Homeostatic Process ABC-type Fatty-acyl-CoA Transporter Activity Catabolic Process Cytosol Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization TRNA-specific Ribonuclease Activity Regulation Of Translation Cytoplasmic Stress Granule Membraneless Organelle Assembly Angiogenin-PRI Complex Negative Regulation Of Catabolic Process Regulation Of Protein Localization Translation Positive Regulation Of Establishment Of Protein Localization XPC Complex RNA Polymerase I Core Binding ERBB3:ERBB2 Complex Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Translation Haptoglobin Binding 5'-deoxynucleotidase Activity Adenosine Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation TOR Signaling Positive Regulation Of Translational Initiation TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity Cellular Response To Rapamycin Regulation Of Translational Initiation Nucleoside Phosphate Catabolic Process Regulation Of Biological Quality Regulation Of Generation Of Precursor Metabolites And Energy Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Import Into Peroxisome Cytoplasmic Translation