NT5E and ZNRF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NT5E	ZNRF4
Description		5'-nucleotidase ecto	zinc and ring finger 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Side Of Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Organelle Membrane
	Molecular Function	Nucleotide Binding 5'-deoxynucleotidase Activity Protein Binding 5'-nucleotidase Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Nucleotide Catabolic Process Response To ATP ADP Catabolic Process ATP Metabolic Process Adenosine Biosynthetic Process Negative Regulation Of Inflammatory Response Calcium Ion Homeostasis Inhibition Of Non-skeletal Tissue Mineralization	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Defense Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction
Pathways		Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		Pentoxifylline
Diseases		Calcification of joints and arteries
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)
Interacting Genes		6 interacting genes: ACTB AFF1 FN1 LAMA1 RNF24 ZNRF4	13 interacting genes: NT5E RIPK2 TPRX1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G2 UBE2N UBE2W UPK2
Entrez ID		4907	148066
HPRD ID		00552	15895
Ensembl ID		ENSG00000135318	ENSG00000105428
Uniprot IDs		P21589 Q6NZX3	Q8WWF5
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6VC9 6VCA 6XUE 6XUG 6XUQ 6YE1 6YE2 6Z9B 6Z9D 7BBJ 7JV8 7JV9 7P9N 7P9R 7P9T 7PA4 7PB5 7PBA 7PBB 7PBY 7PCP 7PD9 7QGA 7QGL 7QGM 7QGO 8ZNZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Regulation Of Transepithelial Transport Blood Microparticle Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Negative Regulation Of Monocyte Activation Calcium-independent Cell-matrix Adhesion Basement Membrane Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Extracellular Matrix Structural Constituent Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Laminin-1 Complex Laminin-3 Complex Laminin Complex BBAF Complex Tat Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cell Adhesion Nitric-oxide Synthase Regulator Activity Cell-cell Junction Postsynaptic Actin Cytoskeleton Cell Adhesion Protein Localization To Adherens Junction Positive Regulation Of Cell Differentiation Dense Body Morphogenesis Of A Polarized Epithelium Establishment Or Maintenance Of Cell Polarity Osteoclast Development Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Neural Crest Cell Migration Involved In Autonomic Nervous System Development Super Elongation Complex Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Glycosphingolipid Binding Protein Complex Involved In Cell-matrix Adhesion Nitric-oxide Synthase Binding Cell Junction Assembly Transporter Activator Activity Endomembrane System Integrin Activation Negative Regulation Of Transforming Growth Factor Beta Production Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Branching Involved In Salivary Gland Morphogenesis	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Transferase Activity Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Proteolysis Regulation Of Protein Polyubiquitination Protein Metabolic Process TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination TOR Signaling Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of TORC1 Signaling Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of TOR Signaling Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Post-translational Protein Modification Adenosine Biosynthetic Process Cellular Response To Nutrient Levels Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Maternal-to-zygotic Transition Of Gene Expression Antiviral Innate Immune Response DNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?