CCN3 and LCE3D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCN3	LCE3D
Description		cellular communication network factor 3	late cornified envelope 3D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Gap Junction Extracellular Matrix Anchoring Junction	Cytosol
	Molecular Function	Signaling Receptor Binding Notch Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Heparin Binding	Protein Binding
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration	Epidermis Development Keratinization
Pathways			Formation of the cornified envelope
Drugs		Insulin human
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Psoriasis ( 19169255 20953190 23143594 25854761)
Interacting Genes		31 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 FXR1 FXR2 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330	69 interacting genes: ADAMTSL4 ALPP CCN3 CHIC2 CYP21A2 CYSRT1 EFEMP1 EFEMP2 FBLN2 HOXA1 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2A LCE2B LCE2C LCE2D MACO1 MDFI NBPF19 NOTCH2NLA PCSK5 RGS17 RGS20 SDC3 SPRY1 SPRY3 SRPK1 SRPK2 TENM4 TGFB1 TRIM42 TSPAN4 VWC2 VWC2L
Entrez ID		4856	84648
HPRD ID		01291	17263
Ensembl ID		ENSG00000136999	ENSG00000163202
Uniprot IDs		P48745	Q9BYE3
PDB IDs
Enriched GO Terms of Interacting Partners?		Tissue Development Epidermis Development Integrin Binding Positive Regulation Of Growth Positive Regulation Of Developmental Growth Regulation Of Growth Regulation Of Developmental Growth Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Receptor Ligand Activity Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Cell Development Regulation Of Nervous System Development Insulin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Angiogenesis Positive Regulation Of Cell Differentiation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Regulation Of Glycogen Biosynthetic Process Basement Membrane Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Response To Wounding Extracellular Region Positive Regulation Of Cell Communication Positive Regulation Of Signaling Integrin-mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Endodermal Cell Differentiation Positive Regulation Of D-glucose Import Cell-matrix Adhesion Regulation Of Neurogenesis Regulation Of Glycogen Metabolic Process Regulation Of Somitogenesis Positive Regulation Of Neurogenesis Regulation Of Skeletal Muscle Tissue Growth	Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Cytosol Keratinization Protein Binding Extracellular Matrix Interstitial Matrix
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