SETD1B and HIST2H3C

Number of citations of the paper that reports this interaction (PMID 22266653)
13

Data Source:
BioGRID (enzymatic study)

		SETD1B	HIST2H3C
Gene Name		SET domain containing 1B	histone cluster 2, H3c
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: HIST1H3A HIST1H3E HIST2H3C WDR5	61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1
Entrez ID		23067	126961
HPRD ID		19516	11822
Ensembl ID		ENSG00000139718
Uniprot IDs		F6MFW1 Q9UPS6	Q71DI3
PDB IDs		3UVO 4ES0	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing DNA Methylation Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Chromatin Organization Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Chromosome Organization DNA Metabolic Process DNA Packaging Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Conformation Change Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gluconeogenesis	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		11q13 aberrations adam29 ash1l assayed cdkn2a consortium crebbp drinking ep300 escc exome fam135b histopathological kmt2c kmt2d microrna mir548k mll2 mll3 nfe2l2 notch1 oesophageal pik3ca rb1 repertoire sixth tumorigenic vast
Tagcloud (Difference) ?		11q13 aberrations adam29 ash1l assayed cdkn2a consortium crebbp drinking ep300 escc exome fam135b histopathological kmt2c kmt2d microrna mir548k mll2 mll3 nfe2l2 notch1 oesophageal pik3ca rb1 repertoire sixth tumorigenic vast
Tagcloud (Intersection) ?