SETD1B and WDR82

Number of citations of the paper that reports this interaction (PubMedID 37030068)
0

Data Source:
BioGRID (pull down)

		SETD1B	WDR82
Description		SET domain containing 1B, histone lysine methyltransferase	WD repeat domain 82
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Histone Methyltransferase Complex Set1C/COMPASS Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Methyltransferase Activity Transferase Activity Histone H3K4 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Chromatin Binding Protein Binding LncRNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Methylation	RNA Polymerase II Promoter Clearance DNA-templated Transcription Termination Gene Expression Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Nuclear RNA Surveillance LncRNA Catabolic Process Negative Regulation Of LncRNA Transcription
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes	Formation of WDR5-containing histone-modifying complexes Nuclear RNA decay
Drugs
Diseases
GWAS		Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 24026423 32888494) Mean spheric corpuscular volume ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) General cognitive ability ( 29844566) Schizophrenia ( 23974872) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: H3C1 H3C14 H3C6 RNF10 WDR82	9 interacting genes: CEBPA EP300 NAGK OSGEP PPP1CA PPP1R10 SETD1B TOX4 TP53
Entrez ID		23067	80335
HPRD ID		19516	15183
Ensembl ID		ENSG00000139718	ENSG00000164091
Uniprot IDs		Q9UPS6	Q6UXN9
PDB IDs		3UVO 4ES0 8ILZ 8WXV
Enriched GO Terms of Interacting Partners?		Gene Expression Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Chromosome Protein-DNA Complex Assembly Protein Heterodimerization Activity Macromolecule Biosynthetic Process Chromatin Remodeling Telomere Organization LncRNA Catabolic Process Negative Regulation Of LncRNA Transcription DNA Binding Chromatin Organization Regulation Of Gene Expression Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process PTW/PP1 Phosphatase Complex Negative Regulation Of Schwann Cell Proliferation RNA Polymerase II Promoter Clearance Epigenetic Regulation Of Gene Expression Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Cadherin Binding Protein-containing Complex Assembly Chromosome Organization Set1C/COMPASS Complex Regulation Of Metabolic Process Protein-containing Complex Organization Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Myelination DNA-templated Transcription Termination Nucleus Chromatin Binding Negative Regulation Of DNA-templated Transcription, Elongation Histone Methyltransferase Complex LncRNA Binding Nuclear RNA Surveillance Nucleoplasm RNA Surveillance Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Extracellular Exosome Postsynaptic Signal Transduction Extracellular Region Protein Monoubiquitination	RNA Polymerase II Promoter Clearance PTW/PP1 Phosphatase Complex Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled DNA-templated Transcription Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Carbohydrate Catabolic Process Protein Stabilization Positive Regulation Of DNA-templated Transcription, Elongation Nucleic Acid Metabolic Process Chromatin DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Generation Of Precursor Metabolites And Energy STAT Family Protein Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Glucose Metabolic Process Lung Development Regulation Of DNA-templated Transcription Elongation Macromolecule Biosynthetic Process Regulation Of Protein Stability Carbohydrate Metabolic Process Circadian Rhythm Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription Elongation By RNA Polymerase II Protein Phosphatase 1 Binding Negative Regulation Of Stem Cell Proliferation Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Chromosome, Telomeric Region Photoperiodism Entrainment Of Circadian Clock Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein-containing Complex Disassembly Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Chromosome Somitogenesis
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