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KDM2A and HIST2H3C
Number of citations of the paper that reports this interaction (PMID
16362057
)
321
Data Source:
BioGRID
(enzymatic study)
HPRD
(two hybrid)
KDM2A
HIST2H3C
Gene Name
lysine (K)-specific demethylase 2A
histone cluster 2, H3c
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Nucleolus
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Molecular Function
Zinc Ion Binding
Unmethylated CpG Binding
Histone Demethylase Activity (H3-K36 Specific)
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Oxidation-reduction Process
Histone H3-K36 Demethylation
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
FOS
HIST2H3C
HIST3H3
RELA
SMAD3
SMAD7
UBC
UBE2G2
ZNF512B
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
Entrez ID
22992
126961
HPRD ID
05741
11822
Ensembl ID
ENSG00000173120
Uniprot IDs
I3VM53
Q9Y2K7
Q71DI3
PDB IDs
2YU1
2YU2
4BBQ
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Toll-like Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of Innate Immune Response
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Chondrocyte Differentiation
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Innate Immune Response
Gene Expression
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Regulation Of Gene Expression, Epigenetic
Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Tagcloud
?
al
architecture
box
cip1
demethylase
demethylases
di
e10
elucidate
embryogenesis
embryonic
et
fbxl10
fbxl11
fukuda
h2a
h3k36
ishimura
jmjd5
knockout
ko
lethality
leucine
mono
pcg
pivotal
polycomb
removes
ubiquitination
Tagcloud (Difference)
?
al
architecture
box
cip1
demethylase
demethylases
di
e10
elucidate
embryogenesis
embryonic
et
fbxl10
fbxl11
fukuda
h2a
h3k36
ishimura
jmjd5
knockout
ko
lethality
leucine
mono
pcg
pivotal
polycomb
removes
ubiquitination
Tagcloud (Intersection)
?