KDM2A

Gene Name		lysine (K)-specific demethylase 2A
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Zinc Ion Binding Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Oxidation-reduction Process Histone H3-K36 Demethylation
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: FOS HIST2H3C HIST3H3 RELA SMAD3 SMAD7 UBC UBE2G2 ZNF512B
Entrez ID		22992
HPRD ID		05741
Ensembl ID		ENSG00000173120
Uniprot IDs		I3VM53 Q9Y2K7
PDB IDs		2YU1 2YU2 4BBQ
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Response To Growth Factor Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Activation Of Innate Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Gene Expression Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		al architecture box cip1 demethylase demethylases di e10 elucidate embryogenesis embryonic et fbxl10 fbxl11 fukuda h2a h3k36 ishimura jmjd5 knockout ko lethality leucine mono pcg pivotal polycomb removes ubiquitination