KDM2A

Name	lysine demethylase 2A
Structure
Novel Interactors	1 novel interactors: POLA2
Interactors	11 interactors: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome
	Molecular Function	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process
Pathways	HDMs demethylate histones
GWAS	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Height ( 28270201 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Mean corpuscular volume ( 27863252 ) Prostate cancer ( 29892016 ) Red blood cell count ( 27863252 32888494 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	22992
HPRD ID	05741
Ensembl ID	ENSG00000173120
Uniprot IDs	I3VM53 I3VM54 Q9Y2K7
PDB IDs	2YU1 2YU2 4BBQ 6BYH 6C16 7UV9
GO Terms Enriched among Interactors ?	Transcription Regulator Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding SMAD Protein Signal Transduction Negative Regulation Of MiRNA Transcription Transcription Coactivator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Cellular Response To Growth Factor Stimulus Chromatin Response To Hormone Beta-catenin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Response To Growth Factor I-SMAD Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Chondrocyte Differentiation Double-stranded DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Intracellular Protein Transport Response To Angiotensin Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muscle Stretch Cellular Response To Cytokine Stimulus R-SMAD Binding Regulation Of T-helper 17 Cell Differentiation Intracellular Signaling Cassette Positive Regulation Of Cell Development Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation NF-kappaB Binding Positive Regulation Of Cartilage Development DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Response To Progesterone Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process