ACIN1 and PCBD1

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		ACIN1	PCBD1
Description		apoptotic chromatin condensation inducer 1	pterin-4 alpha-carbinolamine dehydratase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Lumen Exon-exon Junction Complex ASAP Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding ATP Hydrolysis Activity Enzyme Binding	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding
	Biological Process	MRNA Processing Apoptotic Process RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Apoptotic Process Positive Regulation Of Monocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription
Pathways		Apoptotic cleavage of cellular proteins mRNA Splicing - Major Pathway	Phenylalanine metabolism
Drugs			L-erythro-7,8-dihydrobiopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS			Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)
Interacting Genes		13 interacting genes: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 LINC01554 PAFAH1B2 PCBD1 RNF10 SRPK2 SUMO2 YWHAG	53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714
Entrez ID		22985	5092
HPRD ID		05191	00523
Ensembl ID		ENSG00000100813	ENSG00000166228
Uniprot IDs		B4DQZ7 E7EQT4 Q9UKV3 S4R3H4	P61457
PDB IDs		6G6S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Protein Catabolic Process Positive Regulation Of Metabolic Process Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Epidermal Cell Differentiation Cellular Response To Staurosporine Regulation Of Protein Stability Keratinocyte Differentiation Execution Phase Of Apoptosis Phospholipase A2 Activator Activity Regulation Of Macroautophagy Regulation Of Autophagy Catabolic Process Regulation Of Translational Initiation Protein Localization To Vacuole Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Negative Regulation Of Translational Initiation Symbiont-mediated Disruption Of Host Cell PML Body PML Body Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Presynapse Nuclear Speck Organization Protein Kinase C Inhibitor Activity Ketosteroid Monooxygenase Activity Polyprenol Catabolic Process Negative Regulation Of Retinoic Acid Biosynthetic Process Delta4-3-oxosteroid 5beta-reductase Activity Geranylgeranyl Reductase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Ketoreductase Activity Prostaglandin D2 11-ketoreductase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin F Synthase Activity Farnesol Catabolic Process Cellular Response To Jasmonic Acid Stimulus Regulation Of Isoprenoid Metabolic Process Sesquiterpenoid Metabolic Process Luteolysis Glial Cell Apoptotic Process Positive Regulation Of Aggrephagy 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity	Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition
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