ACIN1 and AKR1C3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		ACIN1	AKR1C3
Description		apoptotic chromatin condensation inducer 1	aldo-keto reductase family 1 member C3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Lumen Exon-exon Junction Complex ASAP Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding ATP Hydrolysis Activity Enzyme Binding	Retinal Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Bile Acid Binding Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase [NAD(P)+] Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Delta4-3-oxosteroid 5beta-reductase Activity All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	MRNA Processing Apoptotic Process RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Apoptotic Process Positive Regulation Of Monocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome	Retinoid Metabolic Process Alcohol Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Male Gonad Development Cellular Response To Starvation Farnesol Catabolic Process Keratinocyte Differentiation Monocarboxylic Acid Metabolic Process Hormone Metabolic Process Progesterone Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Macromolecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Prostanoid Biosynthetic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Testosterone Biosynthetic Process Renal Absorption Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Apoptotic cleavage of cellular proteins mRNA Splicing - Major Pathway	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of Prostaglandins (PG) and Thromboxanes (TX) RA biosynthesis pathway Retinoid metabolism and transport
Drugs			NADH Indomethacin Androstenedione Rutin Prostaglandin D2 Flufenamic acid Nicotinamide adenine dinucleotide phosphate 3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran Olaparib
Diseases
GWAS			Epithelial ovarian cancer ( 31469419) Homeostasis model assessment of insulin resistance ( 33381925)
Interacting Genes		13 interacting genes: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 LINC01554 PAFAH1B2 PCBD1 RNF10 SRPK2 SUMO2 YWHAG	7 interacting genes: ACIN1 HUNK LRIF1 MAGEA11 SIAH2 UBE2W ZHX1
Entrez ID		22985	8644
HPRD ID		05191	04911
Ensembl ID		ENSG00000100813	ENSG00000196139
Uniprot IDs		B4DQZ7 E7EQT4 Q9UKV3 S4R3H4	A0A0A0MSS8 B4DKT3 P42330
PDB IDs		6G6S	1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WDT 4WDU 4WDW 4WDX 4WRH 4XVD 4XVE 4YVV 4YVX 4ZFC 5HNT 5HNU 6A7B 6F2U 6F78 6GXK 7C7F 7C7G 7C7H 7WQM 7WQR 7WQS 7X3L 7X3M 7X3O 8BBS 8I0C 8JP1 8RB6 9FFD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Protein Catabolic Process Positive Regulation Of Metabolic Process Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Epidermal Cell Differentiation Cellular Response To Staurosporine Regulation Of Protein Stability Keratinocyte Differentiation Execution Phase Of Apoptosis Phospholipase A2 Activator Activity Regulation Of Macroautophagy Regulation Of Autophagy Catabolic Process Regulation Of Translational Initiation Protein Localization To Vacuole Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Negative Regulation Of Translational Initiation Symbiont-mediated Disruption Of Host Cell PML Body PML Body Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Presynapse Nuclear Speck Organization Protein Kinase C Inhibitor Activity Ketosteroid Monooxygenase Activity Polyprenol Catabolic Process Negative Regulation Of Retinoic Acid Biosynthetic Process Delta4-3-oxosteroid 5beta-reductase Activity Geranylgeranyl Reductase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Ketoreductase Activity Prostaglandin D2 11-ketoreductase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin F Synthase Activity Farnesol Catabolic Process Cellular Response To Jasmonic Acid Stimulus Regulation Of Isoprenoid Metabolic Process Sesquiterpenoid Metabolic Process Luteolysis Glial Cell Apoptotic Process Positive Regulation Of Aggrephagy 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity
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