PAXIP1 and RPS20

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PAXIP1	RPS20
Description		PAX interacting protein 1	ribosomal protein S20
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Nucleoplasm Cytoplasm Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Cytoplasmic Translation Translation Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Height ( 18391951) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	26 interacting genes: APP BARD1 CREBBP DUX4 ECT2 FOXP1 HMGB1 IL7R MPHOSPH6 NDRG1 NRAS PALS2 PAXIP1 PDE4B PIK3CA PLEKHO1 PTEN RABAC1 REEP6 RNF10 SP3 SUN2 TNFAIP3 TRAF6 USP40 ZNF598
Entrez ID		22976	6224
HPRD ID		08491	04728
Ensembl ID		ENSG00000157212	ENSG00000008988
Uniprot IDs		Q6ZW49	P60866
PDB IDs		3SQD	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Positive Regulation Of Immune System Process Regulation Of Immune Response Myeloid Leukocyte Activation Leukocyte Activation Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Multicellular Organismal-level Homeostasis Immune System Process Regulation Of Interleukin-1 Beta Production Cellular Response To Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Regulation Of Adaptive Immune Response Regulation Of Interleukin-1 Production DNA Recombination Regulation Of Apoptotic Process Activation Of Immune Response Myeloid Progenitor Cell Differentiation Intracellular Signal Transduction Regulation Of Programmed Cell Death Response To Radiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Regulation Of Immune System Process Cell Activation Involved In Immune Response Response To Lipopolysaccharide Positive Regulation Of Signal Transduction Macrophage Activation RAGE Receptor Binding Regulation Of Tumor Necrosis Factor Production Response To Stress Damaged DNA Binding Mononuclear Cell Differentiation Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Cellular Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Hemopoiesis Regulation Of Developmental Process Nucleus Immune Response-activating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin
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