Wiki-Pi
About
Search
People
Updates
Search
RPS20 and NRAS
Number of citations of the paper that reports this interaction (PubMedID
18624398
)
0
Data Source:
BioGRID
(two hybrid)
RPS20
NRAS
Description
ribosomal protein S20
NRAS proto-oncogene, GTPase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Ribosome
Small Ribosomal Subunit
Membrane
Cytosolic Ribosome
Cytosolic Small Ribosomal Subunit
Synapse
Extracellular Exosome
Ribonucleoprotein Complex
Golgi Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Extracellular Exosome
Tertiary Granule Membrane
Molecular Function
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
MDM2/MDM4 Family Protein Binding
Ubiquitin Ligase Inhibitor Activity
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein-containing Complex Binding
Biological Process
Cytoplasmic Translation
Translation
Positive Regulation Of Signal Transduction By P53 Class Mediator
MAPK Cascade
Positive Regulation Of Endothelial Cell Proliferation
Signal Transduction
Ras Protein Signal Transduction
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
SARS-CoV-1 modulates host translation machinery
SARS-CoV-2 modulates host translation machinery
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by RAS GAP mutants
Signaling by RAS GTPase mutants
Drugs
Diseases
Adrenal carcinoma
Acute myeloid leukemia (AML)
Oral cancer
Multiple myeloma
Malignant melanoma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Hepatocellular carcinoma
Thyroid cancer
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Height (
18391951
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
28714469
)
Adult body size (
32376654
)
Autism (
24189344
)
Interacting Genes
26 interacting genes:
APP
BARD1
CREBBP
DUX4
ECT2
FOXP1
HMGB1
IL7R
MPHOSPH6
NDRG1
NRAS
PALS2
PAXIP1
PDE4B
PIK3CA
PLEKHO1
PTEN
RABAC1
REEP6
RNF10
SP3
SUN2
TNFAIP3
TRAF6
USP40
ZNF598
48 interacting genes:
ACVR1
AKT1
ALDOB
AOPEP
ARAF
ARHGAP4
BCL2
CCDC180
CORO2A
CYLC2
DNAJB1
EEF1A1
FANCC
FBP2
FRAT2
HEMGN
HRAS
ITCH
LEF1
LZTR1
MAPK3
MAPKAP1
MTOR
NEDD4
PIK3CA
PIK3CG
PLCE1
PPP2CB
RACGAP1
RAF1
RAP1GDS1
RASGRP2
RASSF5
RGL2
RGL3
RPS20
SFRP4
SHOC2
SMAD1
SMAD4
SMURF2
SRI
STX17
TDRD7
TRMO
WDR76
XPA
ZDHHC9
Entrez ID
6224
4893
HPRD ID
04728
01273
Ensembl ID
ENSG00000008988
ENSG00000213281
Uniprot IDs
P60866
P01111
Q5U091
PDB IDs
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6FEC
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7K5I
7QP6
7QP7
7R4X
7TQL
7XNX
7XNY
8G5Y
8G60
8G61
8G6J
8GLP
8IFD
8IFE
8JDJ
8JDK
8JDL
8JDM
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8Y0W
8Y0X
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
2N9C
3CON
5UHV
6E6H
6MPP
6ULI
6ULK
6ULN
6ULR
6UON
6WGH
6ZIO
6ZIR
6ZIZ
7F68
7OW3
7OW4
7OW5
7OW6
7PB2
8TBI
8VM2
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Myeloid Leukocyte Activation
Leukocyte Activation
Cell Activation
Regulation Of Cell Population Proliferation
Positive Regulation Of Immune Response
Multicellular Organismal-level Homeostasis
Immune System Process
Regulation Of Interleukin-1 Beta Production
Cellular Response To Stress
Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Positive Regulation Of Macromolecule Metabolic Process
DNA Damage Response
Regulation Of Adaptive Immune Response
Regulation Of Interleukin-1 Production
DNA Recombination
Regulation Of Apoptotic Process
Activation Of Immune Response
Myeloid Progenitor Cell Differentiation
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Response To Radiation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Metabolic Process
Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Interleukin-6 Production
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Differentiation
Regulation Of Immune System Process
Cell Activation Involved In Immune Response
Response To Lipopolysaccharide
Positive Regulation Of Signal Transduction
Macrophage Activation
RAGE Receptor Binding
Regulation Of Tumor Necrosis Factor Production
Response To Stress
Damaged DNA Binding
Mononuclear Cell Differentiation
Response To Molecule Of Bacterial Origin
Regulation Of Interleukin-12 Production
Cellular Response To Lipopolysaccharide
Regulation Of Interleukin-2 Production
Hemopoiesis
Regulation Of Developmental Process
Nucleus
Immune Response-activating Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Intracellular Signaling Cassette
Insulin Receptor Signaling Pathway
Signal Transduction
Regulation Of Signal Transduction
Cytosol
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytoplasm
Regulation Of Small GTPase Mediated Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Population Proliferation
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
ERBB Signaling Pathway
Ras Protein Signal Transduction
Positive Regulation Of Cell Migration
BMP Signaling Pathway
MAPK Cascade
Positive Regulation Of Cell Motility
Anoikis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Cellular Component Organization
Channel Inhibitor Activity
Programmed Cell Death
Cellular Response To Insulin Stimulus
Regulation Of Protein Catabolic Process
Regulation Of Autophagy
Cell Death
Small GTPase-mediated Signal Transduction
Regulation Of Ras Protein Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Gland Development
Negative Regulation Of Autophagy
Protein Serine/threonine Kinase Activity
Regulation Of Cell Growth
Lymphocyte Proliferation
Schwann Cell Development
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?