PAXIP1 and CYB5R4

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PAXIP1	CYB5R4
Description		PAX interacting protein 1	cytochrome b5 reductase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Heme Binding Metal Ion Binding
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Detection Of Oxygen Superoxide Metabolic Process Bicarbonate Transport Insulin Secretion Glucose Homeostasis Response To Antibiotic Cell Development Reactive Oxygen Species Metabolic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Erythrocytes take up carbon dioxide and release oxygen
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	1 interacting genes: PAXIP1
Entrez ID		22976	51167
HPRD ID		08491	12218
Ensembl ID		ENSG00000157212	ENSG00000065615
Uniprot IDs		Q6ZW49	Q7L1T6
PDB IDs		3SQD	3LF5 6MV1 6MV2
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Chorion Development MLL3/4 Complex Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of DNA Recombination Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Immunoglobulin Production Histone Methyltransferase Complex Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Isotype Switching Endothelial Cell Migration Regulation Of DNA-templated Transcription Initiation Vasculogenesis Regulation Of Immunoglobulin Production Regulation Of Transcription Initiation By RNA Polymerase II Connective Tissue Development Positive Regulation Of B Cell Activation Positive Regulation Of Post-translational Protein Modification Regulation Of B Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Cycle G2/M Phase Transition Nuclear Matrix Signal Transduction By P53 Class Mediator Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Adaptive Immune Response Regulation Of DNA Recombination Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of DNA-binding Transcription Factor Activity Regulation Of Protein Ubiquitination Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response DNA Recombination Regulation Of Post-translational Protein Modification Positive Regulation Of Immune Effector Process Positive Regulation Of DNA Metabolic Process
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