PAXIP1 and SPATA18

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PAXIP1	SPATA18
Description		PAX interacting protein 1	spermatogenesis associated 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Intracellular Membrane-bounded Organelle Intracellular Membraneless Organelle
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Molecular Condensate Scaffold Activity Cardiolipin Binding
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	CDP-diacylglycerol Biosynthetic Process Cardiolipin Biosynthetic Process Mitochondrial Protein Catabolic Process Mitophagy By Internal Vacuole Formation Cardiolipin Acyl-chain Remodeling Positive Regulation Of Cardiolipin Metabolic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Platelet count ( 29403010) Type 2 diabetes ( 30054458) Uterine fibroids ( 30194396)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	13 interacting genes: AIMP2 CARD10 CCDC102B DRC4 EFHC2 GOLGA2 HOXA1 LRIF1 MAD1L1 PAXIP1 PIBF1 TACC3 TGM7
Entrez ID		22976	132671
HPRD ID		08491	14050
Ensembl ID		ENSG00000157212	ENSG00000163071
Uniprot IDs		Q6ZW49	A0A140VKF4 Q8TC71
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Positive Regulation Of Protein Modification Process Ciliary Basal Body Cytoskeleton Mitotic Spindle Organization Regulation Of Protein Modification Process Mitotic Spindle Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Microtubule-based Process Positive Regulation Of Protein Metabolic Process Spindle Organization Spindle Pole Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Mitotic Spindle Assembly Semicircular Canal Formation MAD1 Complex Abducens Nerve Formation Optokinetic Behavior Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Negative Regulation Of Prostaglandin Biosynthetic Process Microtubule Spindle Assembly Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Chorion Development
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