PAXIP1 and MT-ND1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PAXIP1	MT-ND1
Description		PAX interacting protein 1	NADH dehydrogenase subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Respiratory Chain Complex I
	Molecular Function	Protein Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Response To Hypoxia Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Response To Xenobiotic Stimulus Mitochondrial Respiratory Chain Complex I Assembly Response To Hydroperoxide Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Mitochondrial translation termination Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs			NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate
Diseases			Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	13 interacting genes: BARD1 BRCA1 DHDDS FAT1 LIG4 MEOX2 NDUFS7 PAXIP1 RPL13A RPL6 SIRPA TSC1 TST
Entrez ID		22976	4535
HPRD ID		08491	08365
Ensembl ID		ENSG00000157212	ENSG00000198888
Uniprot IDs		Q6ZW49	P03886 U5Z754
PDB IDs		3SQD	5XTC 5XTD
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Response To Ionizing Radiation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cell Cycle G2/M Phase Transition Large Ribosomal Subunit Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Cellular Response To Radiation Response To Radiation Condensed Chromosome Homologous Recombination DNA Repair Mitotic G2/M Transition Checkpoint Cellular Response To Stress Negative Regulation Of MRNA 3'-end Processing Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Establishment Of Integrated Proviral Latency Memory T Cell Differentiation Negative Regulation Of Formation Of Translation Preinitiation Complex Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Cytosolic Large Ribosomal Subunit Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Establishment Of Viral Latency Cyanate Catabolic Process 3-mercaptopyruvate Sulfurtransferase Activity Negative Regulation Of Cytoplasmic Translational Initiation Cellular Response To Type II Interferon Cellular Response To Interleukin-12 DNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Ubiquitin Ligase Complex DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoprotein Complex DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination
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