RPS20 and ECT2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RPS20	ECT2
Gene Name		ribosomal protein S20	epithelial cell transforming 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Height ( 18391951)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: APP BARD1 ECT2 IL7R MPHOSPH6 MPP6 NDRG1 NRAS PAXIP1 PIK3CA PLEKHO1 RABAC1 REEP6 SUN2	37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2
Entrez ID		6224	1894
HPRD ID		04728	11860
Ensembl ID			ENSG00000114346
Uniprot IDs		P60866	G5E9L8 Q9H8V3
PDB IDs		3J3A	3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Maturation Of 5.8S RRNA Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Cell Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Cell Activation Visual Learning Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Visual Behavior Movement Of Cell Or Subcellular Component Response To Stress Positive Regulation Of Histone H3-K36 Methylation Regulation Of DNA Recombination Anatomical Structure Morphogenesis Regulation Of Immune Response DNA Damage Response, Signal Transduction By P53 Class Mediator Endothelial Cell Migration Positive Regulation Of Protein Modification Process Associative Learning Regulation Of Lymphocyte Activation Regulation Of Cell Cycle Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction In Response To DNA Damage Hypomethylation Of CpG Island Synaptic Growth At Neuromuscular Junction Interleukin-7-mediated Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Blood Coagulation Regulation Of Multicellular Organism Growth Hemostasis Epithelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Transport Epithelium Migration Cell Morphogenesis Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Regulation Of Protein Phosphorylation Signal Transduction By P53 Class Mediator	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition
Tagcloud ?		30s 5a 60s amongst atub bestkeeper cyp ef foundation gapdh genorm ginseng housekeeping iia ingredients medicines normalization normfinder optimum panax popular qcr qrt ranked reference rpl13 sar1 stems transcriptomics	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Difference) ?		30s 5a 60s amongst atub bestkeeper cyp ef foundation gapdh genorm ginseng housekeeping iia ingredients medicines normalization normfinder optimum panax popular qcr qrt ranked reference rpl13 sar1 stems transcriptomics	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Intersection) ?