PAXIP1 and TCN2

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		PAXIP1	TCN2
Gene Name		PAX interacting (with transcription-activation domain) protein 1	transcobalamin II
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Extracellular Region Extracellular Space Endosome Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Cobalamin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cobalt Ion Transport Cobalamin Metabolic Process Cobalamin Transport Small Molecule Metabolic Process
Pathways			Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	3 interactors: APP CBL PAXIP1
Entrez ID		22976	6948
HPRD ID		08491	02037
Ensembl ID		ENSG00000157212	ENSG00000185339
Uniprot IDs		Q6ZW49	P20062
PDB IDs		3SQD	2BB5
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Histone H3-K36 Methylation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Cellular Amino Acid Metabolic Process Chorion Development Response To Radiation Neuron Remodeling Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of DNA-templated Transcription, Initiation Cellular Copper Ion Homeostasis Cellular Protein Modification Process Positive Regulation Of Histone Acetylation Regulation Of DNA-templated Transcription, Initiation Copper Ion Homeostasis Suckling Behavior Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Histone H3-K4 Methylation Mating Behavior Regulation Of Isotype Switching Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Immunoglobulin Mediated Immune Response RNA Polyadenylation Neuron Recognition Positive Regulation Of Receptor-mediated Endocytosis Adipose Tissue Development Positive Regulation Of Histone Methylation Positive Regulation Of Immunoglobulin Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of ERBB Signaling Pathway Regulation Of Histone Acetylation
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	1561c 677c 776g 80g accumulated aggravate b12 consequences defects deficiency folate gcp2 genetic hcy homocysteine hyperhomocysteinemia learned metabolism mthfr much neural nutrient pharmacogenetic polymorphisms rfc1 thcy tube variants vitamin
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	1561c 677c 776g 80g accumulated aggravate b12 consequences defects deficiency folate gcp2 genetic hcy homocysteine hyperhomocysteinemia learned metabolism mthfr much neural nutrient pharmacogenetic polymorphisms rfc1 thcy tube variants vitamin
Tagcloud (Intersection) ?