RPS20 and MPHOSPH6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		RPS20	MPHOSPH6
Description		ribosomal protein S20	M-phase phosphoprotein 6
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Extracellular Exosome Ribonucleoprotein Complex	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity	RNA Binding Protein Binding
	Biological Process	Cytoplasmic Translation Translation Positive Regulation Of Signal Transduction By P53 Class Mediator	Maturation Of 5.8S RRNA RRNA Processing
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Height ( 18391951) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469)	Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Seasonality and depression ( 30217971)
Interacting Genes		26 interacting genes: APP BARD1 CREBBP DUX4 ECT2 FOXP1 HMGB1 IL7R MPHOSPH6 NDRG1 NRAS PALS2 PAXIP1 PDE4B PIK3CA PLEKHO1 PTEN RABAC1 REEP6 RNF10 SP3 SUN2 TNFAIP3 TRAF6 USP40 ZNF598	28 interacting genes: AATF APLP1 ARHGAP18 CRYAA DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		6224	10200
HPRD ID		04728	16111
Ensembl ID		ENSG00000008988	ENSG00000135698
Uniprot IDs		P60866	H3BNT4 Q99547
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Regulation Of Immune Response Myeloid Leukocyte Activation Leukocyte Activation Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Multicellular Organismal-level Homeostasis Immune System Process Regulation Of Interleukin-1 Beta Production Cellular Response To Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Regulation Of Adaptive Immune Response Regulation Of Interleukin-1 Production DNA Recombination Regulation Of Apoptotic Process Activation Of Immune Response Myeloid Progenitor Cell Differentiation Intracellular Signal Transduction Regulation Of Programmed Cell Death Response To Radiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Regulation Of Immune System Process Cell Activation Involved In Immune Response Response To Lipopolysaccharide Positive Regulation Of Signal Transduction Macrophage Activation RAGE Receptor Binding Regulation Of Tumor Necrosis Factor Production Response To Stress Damaged DNA Binding Mononuclear Cell Differentiation Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Cellular Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Hemopoiesis Regulation Of Developmental Process Nucleus Immune Response-activating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) 3'-5'-RNA Exonuclease Activity Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity SnRNA Metabolic Process MRNA Metabolic Process RNA 3'-end Processing RNA Catabolic Process RNA Binding Nuclear-transcribed MRNA Catabolic Process SnRNA Catabolic Process Nuclear RNA Surveillance CUT Catabolic Process RNA Surveillance Regulation Of Female Gonad Development Regulation Of Telomere Maintenance Via Telomerase RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Catabolic Process U4 SnRNA 3'-end Processing Identical Protein Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus RRNA 3'-end Processing Euchromatin TRNA Decay Nuclear MRNA Surveillance Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Telomerase RNA Localization To Cajal Body MDM2/MDM4 Family Protein Binding DNA Deamination Negative Regulation Of Metabolic Process Nucleobase-containing Compound Catabolic Process Response To Heat Regulation Of DNA Biosynthetic Process RRNA Processing Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA Regulation Of Cell Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Apoptotic Process
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