PAXIP1 and FUCA1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		PAXIP1	FUCA1
Gene Name		PAX interacting (with transcription-activation domain) protein 1	fucosidase, alpha-L- 1, tissue
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Cytoplasm Lysosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Alpha-L-fucosidase Activity Fucose Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Fucose Metabolic Process Glycosaminoglycan Catabolic Process Glycoside Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	4 interactors: APP BARD1 PAXIP1 VAV2
Entrez ID		22976	2517
HPRD ID		08491	01974
Ensembl ID		ENSG00000157212	ENSG00000179163
Uniprot IDs		Q6ZW49	P04066
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Positive Regulation Of Histone H3-K36 Methylation Negative Regulation Of MRNA 3'-end Processing Synaptic Growth At Neuromuscular Junction Platelet Activation Positive Regulation Of Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Axon Choice Point Recognition Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination Chorion Development Neuron Remodeling Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Blood Coagulation Regulation Of Gene Expression Blood Vessel Morphogenesis Hemostasis Response To Radiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Blood Vessel Development Regulation Of MRNA 3'-end Processing Axonogenesis Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of Protein Metabolic Process Vasculature Development Cellular Copper Ion Homeostasis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Histone Acetylation Positive Regulation Of Programmed Cell Death DNA Repair Wound Healing Chemotaxis Regulation Of DNA-templated Transcription, Initiation Copper Ion Homeostasis Suckling Behavior Regulation Of Histone H3-K4 Methylation
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	1p34 2q24 2q31 band chromosomal chromosome col3a1 digital fluorescent former fucosidase gave hybridization imaging latter linkage localization localized lod mapped maximal microscopy p36 pseudogene q32 recombination scores situ
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	1p34 2q24 2q31 band chromosomal chromosome col3a1 digital fluorescent former fucosidase gave hybridization imaging latter linkage localization localized lod mapped maximal microscopy p36 pseudogene q32 recombination scores situ
Tagcloud (Intersection) ?