PAXIP1 and FUCA1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PAXIP1	FUCA1
Description		PAX interacting protein 1	alpha-L-fucosidase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Extracellular Region Cytoplasm Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Carbohydrate Metabolic Process Fucose Metabolic Process Lipid Metabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Neutrophil degranulation Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases			Fucosidosis
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Arterial stiffness index ( 31235810) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	8 interacting genes: APP BARD1 CIB1 MED10 OGT PAXIP1 UBQLN2 VAV2
Entrez ID		22976	2517
HPRD ID		08491	01974
Ensembl ID		ENSG00000157212	ENSG00000179163
Uniprot IDs		Q6ZW49	P04066
PDB IDs		3SQD	7PLS 7PM4
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of ATP Metabolic Process Intracellular Signal Transduction Regulation Of Receptor Internalization Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Proteolysis Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Regulation Of DNA-templated Transcription Initiation Acetylcholine Receptor Activator Activity Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Response To Radiation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity
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