PAXIP1 and EIF5B

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		PAXIP1	EIF5B
Gene Name		PAX interacting (with transcription-activation domain) protein 1	eukaryotic translation initiation factor 5B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Cytosol
	Molecular Function	Protein Binding	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways			Translation GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	9 interactors: BRCA1 CBL CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 TFCP2 ZBTB3
Entrez ID		22976	9669
HPRD ID		08491	07304
Ensembl ID		ENSG00000157212	ENSG00000158417
Uniprot IDs		Q6ZW49	O60841 Q8N5A0
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Positive Regulation Of Histone H3-K4 Methylation Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Histone Acetylation Regulation Of Histone Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Hydrogen Peroxide Regulation Of Organelle Organization Regulation Of Cell Cycle Positive Regulation Of Histone Modification Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Response To Abiotic Stimulus Response To Radiation Negative Regulation Of Cell Cycle Gene Expression Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Cell Cycle Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Transcription, DNA-templated Signal Transduction By P53 Class Mediator RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Angiogenesis Response To Hydrogen Peroxide Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally
Tagcloud (Intersection) ?