PAXIP1 and MAPRE2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PAXIP1	MAPRE2
Gene Name		PAX interacting (with transcription-activation domain) protein 1	microtubule-associated protein, RP/EB family, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Cytoplasm Microtubule Cytoskeleton Microtubule Plus-end
	Molecular Function	Protein Binding	Microtubule Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Mitotic Nuclear Division Signal Transduction Cell Proliferation Cell Division
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	17 interactors: APC APP AURKA AURKB CDK2 CDK4 CLASP2 CLIP1 CRTAC1 LMO2 MAPRE1 MAPRE3 NIF3L1 PAXIP1 TRAF1 TRAIP TXN2
Entrez ID		22976	10982
HPRD ID		08491	16157
Ensembl ID		ENSG00000157212	ENSG00000166974
Uniprot IDs		Q6ZW49	G5E9I6 Q15555
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Regulation Of Microtubule Polymerization Or Depolymerization Mitotic Nuclear Division Negative Regulation Of Microtubule Polymerization Or Depolymerization Cell Division Mitotic Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of Protein Binding Regulation Of Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Cell Cycle Process Regulation Of Binding Positive Regulation Of Cell Cycle Negative Regulation Of Cytoskeleton Organization Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Cycle Process Microtubule Cytoskeleton Organization Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Microtubule Plus-end Binding Microtubule-based Process Regulation Of Cell Cycle Process Regulation Of Protein Depolymerization Mitotic Cell Cycle Phase Transition Regulation Of Cytoskeleton Organization Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Regulation Of Protein Complex Disassembly Regulation Of Organelle Organization Regulation Of Cell Cycle Histone Phosphorylation Spindle Stabilization Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Binding Negative Regulation Of Cell Cycle Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Microtubule Polymerization Histone-serine Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Binding Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Positive Regulation Of Cellular Biosynthetic Process Protein Localization To Cytoskeleton Regulation Of Protein Complex Assembly
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	100nm 48h 81m anapc13 calm2 carcinogenic diarrheic drawing exhaustive explanation hn1 malat1 mllt11 molluscs oa okadaic pathologies poisoning positives pttg1 rodents sga shellfish shsy5y ssh subtractive tax1bp1 toxins tumourigenesis
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	100nm 48h 81m anapc13 calm2 carcinogenic diarrheic drawing exhaustive explanation hn1 malat1 mllt11 molluscs oa okadaic pathologies poisoning positives pttg1 rodents sga shellfish shsy5y ssh subtractive tax1bp1 toxins tumourigenesis
Tagcloud (Intersection) ?