PAXIP1 and PLCD1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		PAXIP1	PLCD1
Gene Name		PAX interacting (with transcription-activation domain) protein 1	phospholipase C, delta 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Phosphatidylserine Binding Phosphatidylinositol Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding GTPase Activating Protein Binding Phosphatidic Acid Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Angiogenesis Phospholipid Metabolic Process Lipid Catabolic Process Intracellular Signal Transduction Regulation Of Cell Proliferation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Labyrinthine Layer Blood Vessel Development
Pathways			Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	8 interactors: APP CALM1 GAP43 KPNB1 PAXIP1 RALA RALB TGM2
Entrez ID		22976	5333
HPRD ID		08491	09073
Ensembl ID		ENSG00000157212	ENSG00000187091
Uniprot IDs		Q6ZW49	A8K8F9 P51178
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Axon Choice Point Recognition Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition Regulation Of Filopodium Assembly Positive Regulation Of Cellular Component Biogenesis Response To External Stimulus Exocytosis Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Platelet Degranulation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Regulation Of Exocyst Assembly Response To Radiation Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Cellular Ketone Metabolic Process Secretion By Cell Cytokinesis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Synaptic Growth At Neuromuscular Junction Positive Regulation Of Autophagic Vacuole Assembly Regulation Of Exocyst Localization Positive Regulation Of Vacuole Organization Regulation Of Cell Projection Assembly Cellular Response To Growth Factor Stimulus Cell Recognition Vesicle-mediated Transport Wound Healing Chemotaxis Response To Growth Factor Secretion Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Exocytosis Response To Wounding Membrane Raft Localization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Protein Kinase Activity Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of High Voltage-gated Calcium Channel Activity
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcb2 plce potentiate quiescent react transduction tuned umbilical upcoming
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcb2 plce potentiate quiescent react transduction tuned umbilical upcoming
Tagcloud (Intersection) ?