PAXIP1 and WDR48

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PAXIP1	WDR48
Description		PAX interacting protein 1	WD repeat domain 48
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Late Endosome Cytosol
	Molecular Function	Protein Binding	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Deubiquitinase Activator Activity Ubiquitin Binding
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Single Fertilization Male Gonad Development Multicellular Organism Growth Skin Development Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Seminiferous Tubule Development Regulation Of Primary Metabolic Process Regulation Of Protein Monoubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	7 interacting genes: NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC USP1
Entrez ID		22976	57599
HPRD ID		08491	11146
Ensembl ID		ENSG00000157212	ENSG00000114742
Uniprot IDs		Q6ZW49	A0A024R2L1 Q8TAF3
PDB IDs		3SQD	5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ 7AY0 7AY1 7AY2 8A9J 8A9K 9EBS 9HNW
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex	Regulation Of DNA Metabolic Process Response To Radiation DNA Repair DNA Polymerase Binding Replication Fork Processing DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Repair Male Germ Cell Nucleus DNA Damage Response PCNA Complex Replisome Response To Glucoside Positive Regulation Of Error-prone Translesion Synthesis PCNA-p21 Complex Telomere Maintenance DNA Polymerase Processivity Factor Activity Regulation Of DNA Biosynthetic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Metabolic Process Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Spermatocyte Division Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Chorion Development Regulation Of Cellular Response To Stress Telomere Organization Positive Regulation Of DNA Repair Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of DNA Recombination Cellular Response To Cisplatin Response To Ionizing Radiation LncRNA Transcription Response To UV DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Camptothecin Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Radiation Nuclear Ubiquitin Ligase Complex Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Chromosome, Telomeric Region MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication
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