RPS20 and IL7R

Number of citations of the paper that reports this interaction (PubMedID 23151878)
60

Data Source:
BioGRID (unspecified method)

		RPS20	IL7R
Description		ribosomal protein S20	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Extracellular Exosome Ribonucleoprotein Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Cytoplasmic Translation Translation Positive Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of DNA Recombination Cell Morphogenesis B Cell Homeostasis T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Hemopoiesis T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation T Cell Homeostasis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Lymph Node Development Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Height ( 18391951) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469)	Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Eczema ( 31361310) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 19525953 21833088 24076602) Neutrophil percentage of white cells ( 27863252 32888494) Primary biliary cholangitis ( 26394269 21399635 30643196 23000144 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		26 interacting genes: APP BARD1 CREBBP DUX4 ECT2 FOXP1 HMGB1 IL7R MPHOSPH6 NDRG1 NRAS PALS2 PAXIP1 PDE4B PIK3CA PLEKHO1 PTEN RABAC1 REEP6 RNF10 SP3 SUN2 TNFAIP3 TRAF6 USP40 ZNF598	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		6224	3575
HPRD ID		04728	00893
Ensembl ID		ENSG00000008988	ENSG00000168685
Uniprot IDs		P60866	P16871
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	3DI2 3DI3 3UP1 5J11 6P50 6P67 7OPB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Regulation Of Immune Response Myeloid Leukocyte Activation Leukocyte Activation Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Multicellular Organismal-level Homeostasis Immune System Process Regulation Of Interleukin-1 Beta Production Cellular Response To Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Regulation Of Adaptive Immune Response Regulation Of Interleukin-1 Production DNA Recombination Regulation Of Apoptotic Process Activation Of Immune Response Myeloid Progenitor Cell Differentiation Intracellular Signal Transduction Regulation Of Programmed Cell Death Response To Radiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Regulation Of Immune System Process Cell Activation Involved In Immune Response Response To Lipopolysaccharide Positive Regulation Of Signal Transduction Macrophage Activation RAGE Receptor Binding Regulation Of Tumor Necrosis Factor Production Response To Stress Damaged DNA Binding Mononuclear Cell Differentiation Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Cellular Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Hemopoiesis Regulation Of Developmental Process Nucleus Immune Response-activating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin	RNA Binding Ribonucleoprotein Complex Nucleic Acid Binding RNA Processing MRNA Processing RNA Splicing Spliceosomal Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process MRNA Binding Nucleus Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Positive Regulation Of Gene Expression Cytoplasmic Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Spliceosomal Complex Assembly Regulation Of Translation MRNA Stabilization Regulation Of MRNA Processing U4 SnRNP U1 SnRNP 7-methylguanosine Cap Hypermethylation U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Cytosolic Ribosome Regulation Of RNA Splicing Negative Regulation Of Translation U2 SnRNP Positive Regulation Of Translation Ribosome Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability U2-type Spliceosomal Complex Protein-RNA Complex Assembly Methylosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?