PAXIP1 and DYNC2H1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		PAXIP1	DYNC2H1
Gene Name		PAX interacting (with transcription-activation domain) protein 1	dynein, cytoplasmic 2, heavy chain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Golgi Apparatus Cytosol Microtubule Plasma Membrane Axoneme Dynein Complex Motile Primary Cilium Apical Part Of Cell Extracellular Vesicular Exosome Primary Cilium Ciliary Tip
	Molecular Function	Protein Binding	Motor Activity Microtubule Motor Activity ATP Binding ATPase Activity
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Organelle Organization Golgi Organization Determination Of Left/right Symmetry Asymmetric Protein Localization Dorsal/ventral Pattern Formation Protein Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Spinal Cord Motor Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway
Pathways			Organelle biogenesis and maintenance Hedgehog 'off' state MHC class II antigen presentation Signaling by Hedgehog Assembly of the primary cilium Intraflagellar transport Adaptive Immune System
Drugs
Diseases
GWAS			Small-cell lung cancer ( 21118971)
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	2 interactors: DYNC2LI1 PAXIP1
Entrez ID		22976	79659
HPRD ID		08491	10344
Ensembl ID		ENSG00000157212	ENSG00000187240
Uniprot IDs		Q6ZW49	Q8NCM8
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Positive Regulation Of Histone H3-K36 Methylation Chorion Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Histone Acetylation Regulation Of DNA-templated Transcription, Initiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Histone H3-K4 Methylation Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Adipose Tissue Development Positive Regulation Of Histone Methylation Positive Regulation Of Immunoglobulin Production Regulation Of Histone Acetylation Regulation Of Histone Methylation Regulation Of DNA Recombination Positive Regulation Of Histone Modification Positive Regulation Of B Cell Activation DNA Damage Response, Signal Transduction By P53 Class Mediator Endothelial Cell Migration Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Histone Lysine Methylation Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Vasculogenesis Epithelial Cell Migration Epithelium Migration Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Determination Of Left/right Symmetry Signal Transduction By P53 Class Mediator Determination Of Bilateral Symmetry Histone Methylation Regulation Of Histone Modification Anatomical Structure Morphogenesis Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Adaptive Immune Response Positive Regulation Of Protein Complex Assembly Protein Methylation Cilium Assembly Ameboidal-type Cell Migration Regulation Of Adaptive Immune Response Cilium Organization Regulation Of Protein Ubiquitination
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk
Tagcloud (Intersection) ?