PAXIP1 and DYNC2H1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PAXIP1	DYNC2H1
Description		PAX interacting protein 1	dynein cytoplasmic 2 heavy chain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Cytoplasm Golgi Apparatus Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Axoneme Membrane Dynein Complex Motile Cilium Cell Projection Apical Part Of Cell Extracellular Exosome Ciliary Tip 9+2 Motile Cilium
	Molecular Function	Protein Binding	Nucleotide Binding Cytoskeletal Motor Activity Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition	Kidney Development Microtubule-based Movement Golgi Organization Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Protein Processing Spinal Cord Motor Neuron Differentiation Central Nervous System Neuron Differentiation Cell Projection Organization Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cilium Movement Involved In Cell Motility Coronary Vasculature Development Protein Localization To Cilium Non-motile Cilium Assembly
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases			Asphyxiating thoracic dystrophy; Jeune syndrome Short rib-polydactyly syndrome
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Adult body size ( 32376654) Coronary artery disease ( 32469254 33020668) Diisocyanate-induced asthma ( 25918132) Response to lurasidone in schizophrenia ( 29730043) Small-cell lung cancer (survival) ( 21118971) Spine bone mineral density and alcohol drinking ( 28012008) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)
Interacting Genes		90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	4 interacting genes: DYNC2LI1 MTNR1B PAXIP1 RNF10
Entrez ID		22976	79659
HPRD ID		08491	10344
Ensembl ID		ENSG00000157212	ENSG00000187240
Uniprot IDs		Q6ZW49	Q8NCM8
PDB IDs		3SQD	4RH7 8RGG 8RGH
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex
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