MAPRE3 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAPRE3	LHX4
Description		microtubule associated protein RP/EB family member 3	LIM homeobox 4
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GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Microtubule Plus-end Perinuclear Region Of Cytoplasm Spindle Midzone Neuron To Neuron Synapse Mitotic Spindle Astral Microtubule End Microtubule End	Chromatin Nucleus
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Intracellular Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Protein Localization To Microtubule Positive Regulation Of DNA-templated Transcription Behavioral Response To Cocaine Spindle Assembly Cell Division Positive Regulation Of Dendritic Spine Morphogenesis	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Left–right brain asymmetry ( 33723403) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Refractive error ( 32231278)
Interacting Genes		56 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B SPMIP10 SPMIP2 TLE5 TRAIP TRIM14 TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547	54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76
Entrez ID		22924	89884
HPRD ID		16156	03686
Ensembl ID		ENSG00000084764	ENSG00000121454
Uniprot IDs		Q9UPY8	A0A0S2Z5S4 Q969G2
PDB IDs		1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7 7SJ9	5HOD
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Microtubule Cytoskeleton Organization Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Spindle Microtubule Cytoskeleton Organization Microtubule Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Microtubule Plus-end Binding Cytoplasmic Microtubule Organization Regulation Of Microtubule Polymerization Spindle Midzone Protein Binding Cell Projection Organization Chromosome Passenger Complex Positive Regulation Of Protein Polymerization Microtubule Binding Kinetochore Mitotic Spindle Organization Spindle Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Depolymerization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Cilium Disassembly Protein Localization To Cytoskeleton Astral Microtubule Organization Beta-catenin Destruction Complex Regulation Of Signal Transduction By P53 Class Mediator Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Interferon-beta Production Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Regulation Of Epithelial Cell Migration
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