LHX4 and IFT172

Number of citations of the paper that reports this interaction (PMID 10788441)
7

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		LHX4	IFT172
Gene Name		LIM homeobox 4	intraflagellar transport 172
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cilium Axoneme Intraciliary Transport Particle B Vesicle Ciliary Basal Body Primary Cilium Sperm Midpiece Sperm Principal Piece Ciliary Tip Sperm Cytoplasmic Droplet
	Molecular Function	Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Placenta Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Motor Neuron Axon Guidance Organ Morphogenesis Medial Motor Column Neuron Differentiation Negative Regulation Of Apoptotic Process	Neural Tube Closure Heart Looping Organelle Organization Notch Signaling Pathway Smoothened Signaling Pathway Brain Development Epidermis Development Dorsal/ventral Pattern Formation Protein Processing Spinal Cord Motor Neuron Differentiation Cytoplasmic Microtubule Organization Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Palate Development Limb Development Bone Development Hindgut Development Left/right Axis Specification
Pathways			Organelle biogenesis and maintenance Hedgehog 'off' state Signaling by Hedgehog Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS			Calcium levels ( 20705733) Chronic kidney disease ( 20383146) Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		12 interactors: CHCHD2 FDX1L IFT172 ISL1 LDB2 LONRF1 ORC6 SH2D1A SNRNP25 SSX1 TXNDC5 USP2	2 interactors: LHX3 LHX4
Entrez ID		89884	26160
HPRD ID		03686	09576
Ensembl ID			ENSG00000138002
Uniprot IDs		Q969G2	B3KP68 Q9UG01
PDB IDs
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord	Medial Motor Column Neuron Differentiation Somatic Motor Neuron Differentiation Motor Neuron Axon Guidance Spinal Cord Motor Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Spinal Cord Development Placenta Development Central Nervous System Neuron Differentiation Axon Guidance Reproductive Structure Development Reproductive System Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Developmental Process Involved In Reproduction Ventral Spinal Cord Interneuron Specification Neuron Projection Development Spinal Cord Association Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ventral Spinal Cord Interneuron Differentiation Neuron Development Central Nervous System Development Negative Regulation Of Cell Death Organ Morphogenesis Dorsal Spinal Cord Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Single Organism Reproductive Process Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Locomotion Reproductive Process Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Death Generation Of Neurons Pituitary Gland Development Neurogenesis Cell Development
Tagcloud ?		add besides clinician concern congenital correct costly deviation disturb emphasis genetics ghr ghrhr height hesx1 hypothalamus igfr know lhx3 manifestation normality nutrition ones origins pituitary pou1f1 prop1 psychosocial stature	anchors apparatus assembled caenorhabditis centrosomal chlamydomonas cilia cilium displaces dyf elipsa flag gmap210 golgi hspb11 ift20 ift25 ift54 ift54s ift88 immunoprecipitate intraflagellar liss localize motil orthologue orthologues traf3ip1
Tagcloud (Difference) ?		add besides clinician concern congenital correct costly deviation disturb emphasis genetics ghr ghrhr height hesx1 hypothalamus igfr know lhx3 manifestation normality nutrition ones origins pituitary pou1f1 prop1 psychosocial stature	anchors apparatus assembled caenorhabditis centrosomal chlamydomonas cilia cilium displaces dyf elipsa flag gmap210 golgi hspb11 ift20 ift25 ift54 ift54s ift88 immunoprecipitate intraflagellar liss localize motil orthologue orthologues traf3ip1
Tagcloud (Intersection) ?