LHX4 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		LHX4	NRF1
Description		LIM homeobox 4	nuclear respiratory factor 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of expression of SLITs and ROBOs	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		89884	4899
HPRD ID		03686	02930
Ensembl ID		ENSG00000121454	ENSG00000106459
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q16656
PDB IDs		5HOD	8K3D 8K4L
Enriched GO Terms of Interacting Partners?			Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm
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