LHX4 and ARL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX4	ARL2
Description		LIM homeobox 4	ARF like GTPase 2
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GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Lateral Plasma Membrane Ciliary Basal Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Glycolytic Process Protein Folding Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly Regulation Of Aerobic Respiration
Pathways		Regulation of expression of SLITs and ROBOs	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)
Interacting Genes		54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76	7 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1X TBL1XR1 UNC119
Entrez ID		89884	402
HPRD ID		03686	11869
Ensembl ID		ENSG00000121454	ENSG00000213465
Uniprot IDs		A0A0S2Z5S4 Q969G2	P36404
PDB IDs		5HOD	3DOE 3DOF
Enriched GO Terms of Interacting Partners?			Transcription Repressor Complex Histone Deacetylase Complex Positive Regulation Of Peptidyl-tyrosine Phosphorylation Sensory Perception Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Peptidyl-tyrosine Phosphorylation Medial Motor Column Neuron Differentiation
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