LHX4 and MRS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX4	MRS2
Description		LIM homeobox 4	magnesium transporter MRS2
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GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Magnesium Ion Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Lactate Metabolic Process Monoatomic Ion Transport Mitochondrial Magnesium Ion Transmembrane Transport Transmembrane Transport
Pathways		Regulation of expression of SLITs and ROBOs	Miscellaneous transport and binding events
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)
Interacting Genes		54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76	1 interacting genes: LHX4
Entrez ID		89884	57380
HPRD ID		03686	17603
Ensembl ID		ENSG00000121454	ENSG00000124532
Uniprot IDs		A0A0S2Z5S4 Q969G2	A0A0A0MQX2 B4DSN2 Q9HD23
PDB IDs		5HOD	8IP3 8IP4 8IP5 8IP6 8TS1 8TS2 8TS3 8TUL 8TUP
Enriched GO Terms of Interacting Partners?			Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Methyl-CpG Binding Cell Differentiation In Spinal Cord Placenta Development
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